STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
cacna1iVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2349 aa)    
Predicted Functional Partners:
rasgrf1
Ras protein specific guanine nucleotide releasing factor 1.
     
  0.650
rasgrf2
Ras protein-specific guanine nucleotide-releasing factor 2b.
     
  0.650
LOC103473221
Ras protein-specific guanine nucleotide-releasing factor 2a.
     
  0.650
LOC103475112
RAS guanyl releasing protein 4.
     
  0.650
rasgrp3
RAS guanyl releasing protein 3 (calcium and DAG-regulated).
     
  0.650
RASGRP1
RAS guanyl releasing protein 1.
     
  0.650
RASGRP2
RAS guanyl releasing protein 2.
     
  0.650
LOC103464081
Calcium channel, voltage-dependent, R type, alpha 1E subunit a.
  
0.566
CACNA1D
Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
   
0.530
LOC103468620
Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a.
   
0.530
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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