STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mkrn2Makorin, ring finger protein, 2. (399 aa)    
Predicted Functional Partners:
trip12
Thyroid hormone receptor interactor 12.
     
 0.751
hagh
Hydroxyacylglutathione hydrolase.
 
 
  
 0.672
gsk3b
Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.
   
 
 0.644
raf1
Raf-1 proto-oncogene, serine/threonine kinase a.
     
 0.641
HAGHL
Hydroxyacylglutathione hydrolase like.
 
 
  
 0.608
ppard
Peroxisome proliferator-activated receptor delta b.
 
    
 0.597
PPARG
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
 
    
 0.594
rps27a
Ribosomal protein S27a.
    
  0.563
LOC103472964
Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.
   
 
 0.538
gsk3a
Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.
   
 
 0.538
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.