STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mapk8Mitogen-activated protein kinase. (426 aa)    
Predicted Functional Partners:
LOC103471253
Mitogen-activated protein kinase.
  
 
0.991
ENSPREP00000019402
Protein kinase domain-containing protein.
   
 0.985
map2k4
Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.
   
0.985
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
   
 0.970
LOC103479675
Rac family small GTPase 2.
   
 0.969
JUND
BZIP domain-containing protein.
    
 0.969
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.968
c-fos
V-fos FBJ murine osteosarcoma viral oncogene homolog Ab.
    
 0.968
jun
BZIP domain-containing protein; Belongs to the bZIP family.
    
 0.967
LOC103459044
V-fos FBJ murine osteosarcoma viral oncogene homolog Aa.
    
 0.960
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.