rasd1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

rasd1

RAS, dexamethasone-induced 1. (266 aa)

Predicted Functional Partners:

ENSPREP00000015831

0.788

ENSPREP00000015870

0.788

ENSPREP00000015917

0.788

itsn2

0.788

ENSPREP00000007450

0.670

ENSPREP00000008107

0.670

nf1

0.661

met

0.598

LOC103464537

0.598

mst1r

0.598

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000007450	ENSPREP00000008107	ENSPREP00000007450	ENSPREP00000008107	Uncharacterized protein.	Intersectin 1 (SH3 domain protein).	0.956
ENSPREP00000007450	ENSPREP00000015831	ENSPREP00000007450	ENSPREP00000015831	Uncharacterized protein.	Uncharacterized protein.	0.948
ENSPREP00000007450	ENSPREP00000015870	ENSPREP00000007450	ENSPREP00000015870	Uncharacterized protein.	Uncharacterized protein.	0.994
ENSPREP00000007450	ENSPREP00000015917	ENSPREP00000007450	ENSPREP00000015917	Uncharacterized protein.	EH domain-containing protein.	0.947
ENSPREP00000007450	itsn2	ENSPREP00000007450	ENSPREP00000017512	Uncharacterized protein.	Intersectin 2a.	0.948
ENSPREP00000007450	rasd1	ENSPREP00000007450	ENSPREP00000031990	Uncharacterized protein.	RAS, dexamethasone-induced 1.	0.670
ENSPREP00000008107	ENSPREP00000007450	ENSPREP00000008107	ENSPREP00000007450	Intersectin 1 (SH3 domain protein).	Uncharacterized protein.	0.956
ENSPREP00000008107	ENSPREP00000015831	ENSPREP00000008107	ENSPREP00000015831	Intersectin 1 (SH3 domain protein).	Uncharacterized protein.	0.994
ENSPREP00000008107	ENSPREP00000015870	ENSPREP00000008107	ENSPREP00000015870	Intersectin 1 (SH3 domain protein).	Uncharacterized protein.	0.947
ENSPREP00000008107	ENSPREP00000015917	ENSPREP00000008107	ENSPREP00000015917	Intersectin 1 (SH3 domain protein).	EH domain-containing protein.	0.949
ENSPREP00000008107	itsn2	ENSPREP00000008107	ENSPREP00000017512	Intersectin 1 (SH3 domain protein).	Intersectin 2a.	0.947
ENSPREP00000008107	rasd1	ENSPREP00000008107	ENSPREP00000031990	Intersectin 1 (SH3 domain protein).	RAS, dexamethasone-induced 1.	0.670
ENSPREP00000015831	ENSPREP00000007450	ENSPREP00000015831	ENSPREP00000007450	Uncharacterized protein.	Uncharacterized protein.	0.948
ENSPREP00000015831	ENSPREP00000008107	ENSPREP00000015831	ENSPREP00000008107	Uncharacterized protein.	Intersectin 1 (SH3 domain protein).	0.994
ENSPREP00000015831	ENSPREP00000015870	ENSPREP00000015831	ENSPREP00000015870	Uncharacterized protein.	Uncharacterized protein.	0.995
ENSPREP00000015831	ENSPREP00000015917	ENSPREP00000015831	ENSPREP00000015917	Uncharacterized protein.	EH domain-containing protein.	0.952
ENSPREP00000015831	LOC103464537	ENSPREP00000015831	ENSPREP00000005623	Uncharacterized protein.	Macrophage stimulating 1 receptor a.	0.649
ENSPREP00000015831	itsn2	ENSPREP00000015831	ENSPREP00000017512	Uncharacterized protein.	Intersectin 2a.	0.953
ENSPREP00000015831	met	ENSPREP00000015831	ENSPREP00000003866	Uncharacterized protein.	MET proto-oncogene, receptor tyrosine kinase.	0.649
ENSPREP00000015831	mst1r	ENSPREP00000015831	ENSPREP00000031908	Uncharacterized protein.	Macrophage stimulating 1 receptor b.	0.649

page 1 of 4

Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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