LOC103473396 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

LOC103473396

Laminin, gamma 3. (1298 aa)

Predicted Functional Partners:

ENSPREP00000029903

0.959

ENSPREP00000006281

0.958

LOC103466132

0.907

ENSPREP00000032008

0.899

itgb5

0.847

itga6

0.841

LAMB1

0.816

ENSPREP00000005312

0.808

Lamb2

0.808

LOC103467060

0.786

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005312	ENSPREP00000006281	ENSPREP00000005312	ENSPREP00000006281	Uncharacterized protein.	Uncharacterized protein.	0.653
ENSPREP00000005312	ENSPREP00000029903	ENSPREP00000005312	ENSPREP00000029903	Uncharacterized protein.	Uncharacterized protein.	0.650
ENSPREP00000005312	ENSPREP00000032008	ENSPREP00000005312	ENSPREP00000032008	Uncharacterized protein.	Laminin N-terminal domain-containing protein.	0.808
ENSPREP00000005312	LOC103473396	ENSPREP00000005312	ENSPREP00000032029	Uncharacterized protein.	Laminin, gamma 3.	0.808
ENSPREP00000005312	Lamb2	ENSPREP00000005312	ENSPREP00000005381	Uncharacterized protein.	Laminin, beta 2 (laminin S).	0.919
ENSPREP00000005312	itga6	ENSPREP00000005312	ENSPREP00000007002	Uncharacterized protein.	Integrin, alpha 6a; Belongs to the integrin alpha chain family.	0.445
ENSPREP00000006281	ENSPREP00000005312	ENSPREP00000006281	ENSPREP00000005312	Uncharacterized protein.	Uncharacterized protein.	0.653
ENSPREP00000006281	ENSPREP00000032008	ENSPREP00000006281	ENSPREP00000032008	Uncharacterized protein.	Laminin N-terminal domain-containing protein.	0.713
ENSPREP00000006281	LAMB1	ENSPREP00000006281	ENSPREP00000005052	Uncharacterized protein.	Laminin, beta 1a.	0.650
ENSPREP00000006281	LOC103467060	ENSPREP00000006281	ENSPREP00000005513	Uncharacterized protein.	Laminin, beta 2-like.	0.632
ENSPREP00000006281	LOC103473396	ENSPREP00000006281	ENSPREP00000032029	Uncharacterized protein.	Laminin, gamma 3.	0.958
ENSPREP00000006281	Lamb2	ENSPREP00000006281	ENSPREP00000005381	Uncharacterized protein.	Laminin, beta 2 (laminin S).	0.650
ENSPREP00000006281	itga6	ENSPREP00000006281	ENSPREP00000007002	Uncharacterized protein.	Integrin, alpha 6a; Belongs to the integrin alpha chain family.	0.486
ENSPREP00000029903	ENSPREP00000005312	ENSPREP00000029903	ENSPREP00000005312	Uncharacterized protein.	Uncharacterized protein.	0.650
ENSPREP00000029903	ENSPREP00000032008	ENSPREP00000029903	ENSPREP00000032008	Uncharacterized protein.	Laminin N-terminal domain-containing protein.	0.713
ENSPREP00000029903	LAMB1	ENSPREP00000029903	ENSPREP00000005052	Uncharacterized protein.	Laminin, beta 1a.	0.650
ENSPREP00000029903	LOC103467060	ENSPREP00000029903	ENSPREP00000005513	Uncharacterized protein.	Laminin, beta 2-like.	0.632
ENSPREP00000029903	LOC103473396	ENSPREP00000029903	ENSPREP00000032029	Uncharacterized protein.	Laminin, gamma 3.	0.959
ENSPREP00000029903	Lamb2	ENSPREP00000029903	ENSPREP00000005381	Uncharacterized protein.	Laminin, beta 2 (laminin S).	0.650
ENSPREP00000029903	itga6	ENSPREP00000029903	ENSPREP00000007002	Uncharacterized protein.	Integrin, alpha 6a; Belongs to the integrin alpha chain family.	0.486

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.876

expected number of edges:

12

PPI enrichment p-value:

0.000499

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010608

Post-transcriptional regulation of gene expression

7 of 445

1.51

1.99

2.82e-06

GO:0006378

mRNA polyadenylation

3 of 21

2.47

1.92

0.00027

GO:0006417

Regulation of translation

6 of 377

1.52

1.72

3.71e-05

GO:0043489

RNA stabilization

3 of 44

2.15

1.59

0.00090

GO:0017148

Negative regulation of translation

4 of 139

1.78

1.55

0.00054

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

7 of 1169

1.09

0.96

0.00069

GO:0004652

Polynucleotide adenylyltransferase activity

2 of 15

2.44

0.85

0.0281

GO:1901363

Heterocyclic compound binding

10 of 6300

0.52

0.34

0.0281

GO:0097159

Organic cyclic compound binding

10 of 6378

0.51

0.34

0.0281

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37288606

(2023) Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.

3 of 15

2.62

2.3

5.53e-05

PMID:34263725

(2021) A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma.

2 of 21

2.3

0.9

0.0218

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2940

Mixed, incl. Deadenylation-dependent mRNA decay, and Anti-proliferative protein

5 of 90

2.06

2.7

2.52e-06

CL:11094

mRNA cleavage and polyadenylation specificity factor complex

2 of 7

2.77

0.95

0.0189

CL:3058

mRNA decay by 5 to 3 exoribonuclease, and Scd6-like Sm domain

2 of 15

2.44

0.79

0.0367

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04914

Progesterone-mediated oocyte maturation

3 of 88

1.85

1.38

0.0016

pret04114

Oocyte meiosis

3 of 111

1.75

1.34

0.0016

pret03018

RNA degradation

2 of 69

1.78

0.8

0.0284

pret03015

mRNA surveillance pathway

2 of 76

1.74

0.79

0.0284

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8953854

Metabolism of RNA

7 of 895

1.21

1.26

6.94e-05

MAP-429914

Deadenylation-dependent mRNA decay

3 of 74

1.93

1.18

0.0049

MAP-6804114

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

2 of 13

2.5

1.05

0.0122

MAP-77595

Processing of Intronless Pre-mRNAs

2 of 21

2.3

0.9

0.0220

MAP-75067

Processing of Capped Intronless Pre-mRNA

2 of 24

2.24

0.89

0.0226

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