ENSPREP00000032042 protein (Poecilia reticulata)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

ENSPREP00000032042

Ig-like domain-containing protein. (131 aa)

Predicted Functional Partners:

ENSPREP00000028049

0.914

LOC103465013

0.900

LOC103482478

0.806

LOC103459742

0.806

LOC103479782

0.724

LOC103472572

0.686

ENSPREP00000006423

0.478

ENSPREP00000006131

0.477

rpa2

0.468

ENSPREP00000006446

0.463

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006131	ENSPREP00000028049	ENSPREP00000006131	ENSPREP00000028049	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.918
ENSPREP00000006131	ENSPREP00000032042	ENSPREP00000006131	ENSPREP00000032042	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.477
ENSPREP00000006131	LOC103459742	ENSPREP00000006131	ENSPREP00000026352	Ig-like domain-containing protein; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.860
ENSPREP00000006131	LOC103465013	ENSPREP00000006131	ENSPREP00000030400	Ig-like domain-containing protein; Belongs to the MHC class I family.	IGv domain-containing protein.	0.910
ENSPREP00000006131	LOC103472572	ENSPREP00000006131	ENSPREP00000023255	Ig-like domain-containing protein; Belongs to the MHC class I family.	Protein disulfide-isomerase.	0.746
ENSPREP00000006131	LOC103479782	ENSPREP00000006131	ENSPREP00000018198	Ig-like domain-containing protein; Belongs to the MHC class I family.	Calreticulin.	0.792
ENSPREP00000006131	LOC103482478	ENSPREP00000006131	ENSPREP00000026256	Ig-like domain-containing protein; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.860
ENSPREP00000006131	rpa2	ENSPREP00000006131	ENSPREP00000007530	Ig-like domain-containing protein; Belongs to the MHC class I family.	Replication protein A2.	0.617
ENSPREP00000006423	ENSPREP00000028049	ENSPREP00000006423	ENSPREP00000028049	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.918
ENSPREP00000006423	ENSPREP00000032042	ENSPREP00000006423	ENSPREP00000032042	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.478
ENSPREP00000006423	LOC103459742	ENSPREP00000006423	ENSPREP00000026352	Ig-like domain-containing protein; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.860
ENSPREP00000006423	LOC103465013	ENSPREP00000006423	ENSPREP00000030400	Ig-like domain-containing protein; Belongs to the MHC class I family.	IGv domain-containing protein.	0.901
ENSPREP00000006423	LOC103472572	ENSPREP00000006423	ENSPREP00000023255	Ig-like domain-containing protein; Belongs to the MHC class I family.	Protein disulfide-isomerase.	0.746
ENSPREP00000006423	LOC103479782	ENSPREP00000006423	ENSPREP00000018198	Ig-like domain-containing protein; Belongs to the MHC class I family.	Calreticulin.	0.792
ENSPREP00000006423	LOC103482478	ENSPREP00000006423	ENSPREP00000026256	Ig-like domain-containing protein; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.860
ENSPREP00000006423	rpa2	ENSPREP00000006423	ENSPREP00000007530	Ig-like domain-containing protein; Belongs to the MHC class I family.	Replication protein A2.	0.617
ENSPREP00000006446	ENSPREP00000028049	ENSPREP00000006446	ENSPREP00000028049	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.918
ENSPREP00000006446	ENSPREP00000032042	ENSPREP00000006446	ENSPREP00000032042	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.463
ENSPREP00000006446	LOC103459742	ENSPREP00000006446	ENSPREP00000026352	Ig-like domain-containing protein; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.860
ENSPREP00000006446	LOC103465013	ENSPREP00000006446	ENSPREP00000030400	Ig-like domain-containing protein; Belongs to the MHC class I family.	IGv domain-containing protein.	0.901

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.842

expected number of edges:

11

PPI enrichment p-value:

0.0142

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001503

Ossification

7 of 108

2.13

4.4

1.78e-10

GO:0045597

Positive regulation of cell differentiation

7 of 478

1.48

2.07

6.58e-07

GO:2000026

Regulation of multicellular organismal development

9 of 838

1.35

2.0

2.63e-08

GO:0051094

Positive regulation of developmental process

8 of 738

1.35

1.87

3.04e-07

GO:0002062

Chondrocyte differentiation

3 of 45

2.14

1.8

0.00032

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

4 of 371

1.35

0.71

0.0270

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31879

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runt domain

5 of 30

2.54

4.08

1.43e-08

CL:31881

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and FOG family

3 of 21

2.47

2.18

8.33e-05

CL:31886

Mixed, incl. RUNX3 regulates p14-ARF, and LIM interaction domain

2 of 6

2.84

1.42

0.0027

CL:31925

Mixed, incl. Runt domain, and Paired-box protein 2 C-terminal

2 of 7

2.77

1.38

0.0031

CL:41371

Mixed, incl. Ubiquinone and other terpenoid-quinone biosynthesis, and Osteocalcin/matrix Gla protein

2 of 15

2.44

1.09

0.0102

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951936

RUNX3 regulates p14-ARF

2 of 6

2.84

1.36

0.0035

MAP-8939246

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

2 of 4

3.02

1.36

0.0035

MAP-8931987

RUNX1 regulates estrogen receptor mediated transcription

2 of 3

3.14

1.36

0.0035

MAP-8877330

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

2 of 4

3.02

1.36

0.0035

MAP-8934593

Regulation of RUNX1 Expression and Activity

2 of 8

2.72

1.35

0.0035

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00853

Runt domain

4 of 4

3.32

4.59

4.60e-09

PF08504

Runx inhibition domain

3 of 3

3.32

3.17

1.88e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013524

Runt domain

4 of 4

3.32

4.32

1.44e-08

IPR000040

Acute myeloid leukemia 1 protein (AML1)/Runt

4 of 4

3.32

4.32

1.44e-08

IPR012346

p53/RUNT-type transcription factor, DNA-binding domain superfamily

4 of 7

3.07

4.18

2.26e-08

IPR027384

Runx, central domain superfamily

3 of 3

3.32

3.06

2.94e-06

IPR016554

Runt-related transcription factor RUNX

3 of 3

3.32

3.06

2.94e-06

(more ...)

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