STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
huwe1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4580 aa)    
Predicted Functional Partners:
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 0.924
LOC103477645
MCL1 apoptosis regulator, BCL2 family member b.
    
 
 0.921
rps27a
Ribosomal protein S27a.
   
 0.893
ddit4
DNA-damage-inducible transcript 4.
    
 
 0.875
ubb
Uncharacterized protein.
   
 0.838
LOC103473189
Uncharacterized protein.
   
 0.838
trip12
Thyroid hormone receptor interactor 12.
   
 
0.796
ENSPREP00000009964
Ubiquitin-like domain-containing protein.
   
 0.766
wdr82
WD repeat domain 82.
    
 
 0.699
ubr4
Ubiquitin protein ligase E3 component n-recognin 4.
   
 
 0.696
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.