LOC103459138 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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Predicted Interactions

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Score

LOC103459138

NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (299 aa)

Predicted Functional Partners:

Suox

0.966

LOC103478806

0.955

umps

0.944

dpyd

0.929

dhodh

0.929

LOC103462495

0.911

LOC103466256

0.902

LOC103459632

0.901

ENSPREP00000015100

0.842

ENSPREP00000022561

0.800

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000015100	LOC103459138	ENSPREP00000015100	ENSPREP00000033277	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.842
ENSPREP00000015100	LOC103466256	ENSPREP00000015100	ENSPREP00000002677	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.840
ENSPREP00000015100	LOC103478806	ENSPREP00000015100	ENSPREP00000025960	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	Cytochrome b5 reductase 4.	0.833
ENSPREP00000015100	Suox	ENSPREP00000015100	ENSPREP00000021510	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	Sulfite oxidase.	0.701
ENSPREP00000022561	LOC103459138	ENSPREP00000022561	ENSPREP00000033277	Uncharacterized protein.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.800
ENSPREP00000022561	LOC103466256	ENSPREP00000022561	ENSPREP00000002677	Uncharacterized protein.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.800
ENSPREP00000022561	LOC103478806	ENSPREP00000022561	ENSPREP00000025960	Uncharacterized protein.	Cytochrome b5 reductase 4.	0.817
LOC103459138	ENSPREP00000015100	ENSPREP00000033277	ENSPREP00000015100	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.842
LOC103459138	ENSPREP00000022561	ENSPREP00000033277	ENSPREP00000022561	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Uncharacterized protein.	0.800
LOC103459138	LOC103459632	ENSPREP00000033277	ENSPREP00000020203	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Cytidine monophospho-N-acetylneuraminic acid hydroxylase.	0.901
LOC103459138	LOC103462495	ENSPREP00000033277	ENSPREP00000034259	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Cytochrome b5 type B; Belongs to the cytochrome b5 family.	0.911
LOC103459138	LOC103466256	ENSPREP00000033277	ENSPREP00000002677	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.902
LOC103459138	LOC103478806	ENSPREP00000033277	ENSPREP00000025960	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Cytochrome b5 reductase 4.	0.955
LOC103459138	Suox	ENSPREP00000033277	ENSPREP00000021510	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Sulfite oxidase.	0.966
LOC103459138	dhodh	ENSPREP00000033277	ENSPREP00000033422	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Dihydroorotate dehydrogenase.	0.929
LOC103459138	dpyd	ENSPREP00000033277	ENSPREP00000021733	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	0.929
LOC103459138	umps	ENSPREP00000033277	ENSPREP00000023343	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Uridine monophosphate synthetase.	0.944
LOC103459632	LOC103459138	ENSPREP00000020203	ENSPREP00000033277	Cytidine monophospho-N-acetylneuraminic acid hydroxylase.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.901
LOC103459632	LOC103466256	ENSPREP00000020203	ENSPREP00000002677	Cytidine monophospho-N-acetylneuraminic acid hydroxylase.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.901
LOC103459632	LOC103478806	ENSPREP00000020203	ENSPREP00000025960	Cytidine monophospho-N-acetylneuraminic acid hydroxylase.	Cytochrome b5 reductase 4.	0.900

page 1 of 4

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.562

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045664

Regulation of neuron differentiation

6 of 80

2.19

3.85

8.75e-09

GO:0045666

Positive regulation of neuron differentiation

5 of 40

2.41

3.76

4.36e-08

GO:0001711

Endodermal cell fate commitment

2 of 3

3.14

1.83

0.00049

GO:0045597

Positive regulation of cell differentiation

6 of 478

1.42

1.69

1.34e-05

GO:0045944

Positive regulation of transcription by RNA polymerase II

8 of 880

1.28

1.66

7.57e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

7 of 32

2.66

6.95

2.09e-14

GO:0008134

Transcription factor binding

7 of 358

1.61

2.49

1.04e-07

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

6 of 252

1.69

2.43

7.66e-07

GO:0046982

Protein heterodimerization activity

6 of 258

1.68

2.41

7.66e-07

GO:0046983

Protein dimerization activity

7 of 842

1.24

1.42

1.23e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 371

1.59

2.44

1.25e-07

GO:0016593

Cdc73/Paf1 complex

2 of 9

2.66

1.27

0.0048

GO:0005721

Pericentric heterochromatin

2 of 18

2.36

1.03

0.0125

GO:0005634

Nucleus

11 of 6688

0.53

0.43

0.00085

GO:0032991

Protein-containing complex

9 of 5100

0.56

0.39

0.0125

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36459298

(2022) Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.

2 of 20

2.32

0.77

0.0397

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31959

Myogenesis, and DNA-binding protein inhibitor

6 of 24

2.72

5.82

6.88e-12

CL:31867

Mixed, incl. Helix-loop-helix DNA-binding domain superfamily, and RUNX1 regulates transcription of genes involved in differentiation of HSCs

7 of 114

2.11

4.48

7.89e-11

CL:31960

MADS MEF2-like, and Myogenic factor

3 of 15

2.62

2.36

4.20e-05

CL:10560

Endodermal cell fate commitment, and Spinal cord oligodendrocyte cell differentiation

2 of 5

2.92

1.45

0.0024

CL:31990

DNA-binding protein inhibitor, and Positive regulation of skeletal muscle fiber development

2 of 6

2.84

1.4

0.0029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

5 of 54

2.28

3.55

7.30e-08

MAP-1266738

Developmental Biology

6 of 811

1.19

1.06

0.00067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016593

Cdc73/Paf1 complex

2 of 8

2.72

1.23

0.0058

GOCC:0005721

Pericentric heterochromatin

2 of 7

2.77

1.23

0.0058

GOCC:0005634

Nucleus

9 of 3523

0.72

0.55

0.0031

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.3

0.0150

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

5 of 144

1.86

2.07

3.49e-05

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

5 of 145

1.86

2.07

3.49e-05

IPR008251

Chromo shadow domain

2 of 5

2.92

1.1

0.0104

IPR017984

Chromo domain subgroup

2 of 10

2.62

0.89

0.0246

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

5 of 149

1.84

2.38

4.51e-06

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