Eys protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

Eys

Uncharacterized protein. (303 aa)

Predicted Functional Partners:

ENSPREP00000033286

0.887

ENSPREP00000033301

0.843

LOC103469257

0.718

rbpj

0.718

jag1

0.490

ENSPREP00000001685

0.487

LOC103458084

0.487

jag2

0.487

snw1

0.477

LOC103476192

0.463

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000001685	ENSPREP00000033286	ENSPREP00000001685	ENSPREP00000033286	Uncharacterized protein.	Uncharacterized protein.	0.519
ENSPREP00000001685	ENSPREP00000033301	ENSPREP00000001685	ENSPREP00000033301	Uncharacterized protein.	Uncharacterized protein.	0.487
ENSPREP00000001685	Eys	ENSPREP00000001685	ENSPREP00000033305	Uncharacterized protein.	Uncharacterized protein.	0.487
ENSPREP00000001685	LOC103469257	ENSPREP00000001685	ENSPREP00000015443	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region a.	0.537
ENSPREP00000001685	rbpj	ENSPREP00000001685	ENSPREP00000016630	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region.	0.537
ENSPREP00000033286	ENSPREP00000001685	ENSPREP00000033286	ENSPREP00000001685	Uncharacterized protein.	Uncharacterized protein.	0.519
ENSPREP00000033286	Eys	ENSPREP00000033286	ENSPREP00000033305	Uncharacterized protein.	Uncharacterized protein.	0.887
ENSPREP00000033286	LOC103458084	ENSPREP00000033286	ENSPREP00000003595	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.487
ENSPREP00000033286	LOC103469257	ENSPREP00000033286	ENSPREP00000015443	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region a.	0.718
ENSPREP00000033286	LOC103476192	ENSPREP00000033286	ENSPREP00000016604	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.413
ENSPREP00000033286	jag1	ENSPREP00000033286	ENSPREP00000010508	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.487
ENSPREP00000033286	jag2	ENSPREP00000033286	ENSPREP00000023176	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.487
ENSPREP00000033286	rbpj	ENSPREP00000033286	ENSPREP00000016630	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region.	0.718
ENSPREP00000033286	snw1	ENSPREP00000033286	ENSPREP00000027074	Uncharacterized protein.	SNW domain containing 1.	0.477
ENSPREP00000033301	ENSPREP00000001685	ENSPREP00000033301	ENSPREP00000001685	Uncharacterized protein.	Uncharacterized protein.	0.487
ENSPREP00000033301	Eys	ENSPREP00000033301	ENSPREP00000033305	Uncharacterized protein.	Uncharacterized protein.	0.843
ENSPREP00000033301	LOC103458084	ENSPREP00000033301	ENSPREP00000003595	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.487
ENSPREP00000033301	LOC103469257	ENSPREP00000033301	ENSPREP00000015443	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region a.	0.718
ENSPREP00000033301	LOC103476192	ENSPREP00000033301	ENSPREP00000016604	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.413
ENSPREP00000033301	jag1	ENSPREP00000033301	ENSPREP00000010508	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.487

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.928

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001676

Long-chain fatty acid metabolic process

6 of 11

2.31

4.35

1.21e-09

GO:0032787

Monocarboxylic acid metabolic process

8 of 188

1.2

1.45

2.44e-06

GO:0044255

Cellular lipid metabolic process

7 of 158

1.22

1.37

1.53e-05

GO:0019427

acetyl-CoA biosynthetic process from acetate

2 of 4

2.27

1.01

0.0137

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016874

Ligase activity

8 of 137

1.34

1.85

2.41e-07

GO:0016405

CoA-ligase activity

3 of 10

2.05

1.44

0.0016

GO:0016878

Acid-thiol ligase activity

3 of 12

1.97

1.41

0.0017

GO:0016208

AMP binding

2 of 4

2.27

1.2

0.0059

GO:0003987

acetate-CoA ligase activity

2 of 4

2.27

1.2

0.0059

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4084

Long-chain fatty acid metabolic process, and Phosphate acyltransferases

4 of 7

2.33

2.9

2.28e-06

CL:3908

Mixed, incl. Valine, leucine and isoleucine degradation, and Fatty acid metabolic process

7 of 95

1.44

1.92

1.44e-06

CL:5282

Mixed, incl. Sphingolipid metabolic process, and Helix-turn-helix XRE-family like proteins

2 of 6

2.09

0.85

0.0255

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0436

Ligase

8 of 92

1.51

2.54

3.37e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13193

AMP-binding enzyme C-terminal domain

7 of 10

2.41

5.93

5.40e-13

PF00501

AMP-binding enzyme

8 of 17

2.24

5.92

5.86e-14

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000873

AMP-dependent synthetase/ligase domain

8 of 17

2.24

5.76

1.54e-13

IPR025110

AMP-binding enzyme, C-terminal domain

7 of 10

2.41

5.75

1.42e-12

IPR045851

AMP-binding enzyme, C-terminal domain superfamily

7 of 12

2.34

5.51

2.44e-12

IPR020845

AMP-binding, conserved site

7 of 12

2.34

5.51

2.44e-12

IPR042099

ANL, N-terminal domain

7 of 16

2.21

5.08

7.11e-12

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