STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103459816Amyloid beta (A4) precursor protein b. (751 aa)    
Predicted Functional Partners:
sorl1
Sortilin-related receptor, L(DLR class) A repeats containing.
    
 0.903
NCSTN
Nicastrin.
    
 0.899
ide
Insulin-degrading enzyme; Belongs to the peptidase M16 family.
    
 
 0.883
tnfrsf21
Tumor necrosis factor receptor superfamily, member 21.
    
 
 0.861
pitrm1
Pitrilysin metallopeptidase 1.
    
 
 0.852
LOC103477848
Apolipoprotein Eb.
    
 0.815
psen2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 
 0.726
LOC103458271
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 
 0.726
LOC103473856
Uncharacterized protein; Belongs to the synuclein family.
   
 0.726
gulp1
GULP PTB domain containing engulfment adaptor 1a.
    
 
 0.717
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.