STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hps3HPS3 biogenesis of lysosomal organelles complex 2 subunit 1. (1031 aa)    
Predicted Functional Partners:
hps5
Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
   
 
 0.884
HPS6
HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.
   
 
 0.760
lyst
Lysosomal trafficking regulator.
      
 0.669
ap3d1
Adaptor related protein complex 3 subunit delta 1.
      
 0.657
hps4
HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.
      
 0.648
dtnbp1
Dystrobrevin binding protein 1b.
      
 0.646
ap3b1
AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.
      
 0.646
bloc1s3
Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family.
      
 0.643
bloc1s5
Biogenesis of lysosomal organelles complex-1, subunit 5, muted.
      
 0.618
FIG4
FIG4 phosphoinositide 5-phosphatase.
      
 0.614
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.