LOC103464337 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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LOC103464337

Deoxyribonuclease; Belongs to the DNase I family. (269 aa)

Predicted Functional Partners:

LOC103475719

0.491

LOC103472577

0.471

RIMS2

0.471

lamtor2

0.461

ENSPREP00000005404

0.425

ikbkb

0.425

CHUK

0.425

tbk1

0.425

LOC103476976

0.425

lamtor1

0.409

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	LOC103464337	ENSPREP00000020163	ENSPREP00000033810	Component of inhibitor of nuclear factor kappa B kinase complex.	Deoxyribonuclease; Belongs to the DNase I family.	0.425
CHUK	LOC103476976	ENSPREP00000020163	ENSPREP00000032137	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.943
CHUK	ikbkb	ENSPREP00000020163	ENSPREP00000016563	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.950
ENSPREP00000005404	LOC103464337	ENSPREP00000005404	ENSPREP00000033810	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Deoxyribonuclease; Belongs to the DNase I family.	0.425
ENSPREP00000005404	LOC103476976	ENSPREP00000005404	ENSPREP00000032137	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.401
LOC103464337	CHUK	ENSPREP00000033810	ENSPREP00000020163	Deoxyribonuclease; Belongs to the DNase I family.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.425
LOC103464337	ENSPREP00000005404	ENSPREP00000033810	ENSPREP00000005404	Deoxyribonuclease; Belongs to the DNase I family.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.425
LOC103464337	LOC103472577	ENSPREP00000033810	ENSPREP00000023069	Deoxyribonuclease; Belongs to the DNase I family.	Uncharacterized protein.	0.471
LOC103464337	LOC103475719	ENSPREP00000033810	ENSPREP00000031227	Deoxyribonuclease; Belongs to the DNase I family.	Ras-related GTP binding A.	0.491
LOC103464337	LOC103476976	ENSPREP00000033810	ENSPREP00000032137	Deoxyribonuclease; Belongs to the DNase I family.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.425
LOC103464337	RIMS2	ENSPREP00000033810	ENSPREP00000023895	Deoxyribonuclease; Belongs to the DNase I family.	Regulating synaptic membrane exocytosis 2.	0.471
LOC103464337	ikbkb	ENSPREP00000033810	ENSPREP00000016563	Deoxyribonuclease; Belongs to the DNase I family.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.425
LOC103464337	lamtor1	ENSPREP00000033810	ENSPREP00000028765	Deoxyribonuclease; Belongs to the DNase I family.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.409
LOC103464337	lamtor2	ENSPREP00000033810	ENSPREP00000025706	Deoxyribonuclease; Belongs to the DNase I family.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	0.461
LOC103464337	tbk1	ENSPREP00000033810	ENSPREP00000027853	Deoxyribonuclease; Belongs to the DNase I family.	TANK-binding kinase 1.	0.425
LOC103472577	LOC103464337	ENSPREP00000023069	ENSPREP00000033810	Uncharacterized protein.	Deoxyribonuclease; Belongs to the DNase I family.	0.471
LOC103475719	LOC103464337	ENSPREP00000031227	ENSPREP00000033810	Ras-related GTP binding A.	Deoxyribonuclease; Belongs to the DNase I family.	0.491
LOC103475719	lamtor1	ENSPREP00000031227	ENSPREP00000028765	Ras-related GTP binding A.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.997
LOC103475719	lamtor2	ENSPREP00000031227	ENSPREP00000025706	Ras-related GTP binding A.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	0.978
LOC103476976	CHUK	ENSPREP00000032137	ENSPREP00000020163	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.943

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.876

expected number of edges:

12

PPI enrichment p-value:

0.000499

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010608

Post-transcriptional regulation of gene expression

7 of 445

1.51

1.99

2.82e-06

GO:0006378

mRNA polyadenylation

3 of 21

2.47

1.92

0.00027

GO:0006417

Regulation of translation

6 of 377

1.52

1.72

3.71e-05

GO:0043489

RNA stabilization

3 of 44

2.15

1.59

0.00090

GO:0017148

Negative regulation of translation

4 of 139

1.78

1.55

0.00054

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

7 of 1169

1.09

0.96

0.00069

GO:0004652

Polynucleotide adenylyltransferase activity

2 of 15

2.44

0.85

0.0281

GO:1901363

Heterocyclic compound binding

10 of 6300

0.52

0.34

0.0281

GO:0097159

Organic cyclic compound binding

10 of 6378

0.51

0.34

0.0281

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37288606

(2023) Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.

3 of 15

2.62

2.3

5.53e-05

PMID:34263725

(2021) A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma.

2 of 21

2.3

0.9

0.0218

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2940

Mixed, incl. Deadenylation-dependent mRNA decay, and Anti-proliferative protein

5 of 90

2.06

2.7

2.52e-06

CL:11094

mRNA cleavage and polyadenylation specificity factor complex

2 of 7

2.77

0.95

0.0189

CL:3058

mRNA decay by 5 to 3 exoribonuclease, and Scd6-like Sm domain

2 of 15

2.44

0.79

0.0367

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04914

Progesterone-mediated oocyte maturation

3 of 88

1.85

1.38

0.0016

pret04114

Oocyte meiosis

3 of 111

1.75

1.34

0.0016

pret03018

RNA degradation

2 of 69

1.78

0.8

0.0284

pret03015

mRNA surveillance pathway

2 of 76

1.74

0.79

0.0284

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8953854

Metabolism of RNA

7 of 895

1.21

1.26

6.94e-05

MAP-429914

Deadenylation-dependent mRNA decay

3 of 74

1.93

1.18

0.0049

MAP-6804114

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

2 of 13

2.5

1.05

0.0122

MAP-77595

Processing of Intronless Pre-mRNAs

2 of 21

2.3

0.9

0.0220

MAP-75067

Processing of Capped Intronless Pre-mRNA

2 of 24

2.24

0.89

0.0226

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