dpagt1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

dpagt1

Uncharacterized protein. (406 aa)

Predicted Functional Partners:

alg13

0.983

LOC103473139

0.982

alg14

0.974

alg5

0.968

Dolk

0.955

dpm3

0.936

dpm2

0.932

snx12

0.737

alg1

0.730

ENSPREP00000018226

0.715

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dolk	alg1	ENSPREP00000001501	ENSPREP00000020074	Dolichol kinase.	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.	0.727
Dolk	alg5	ENSPREP00000001501	ENSPREP00000017135	Dolichol kinase.	ALG5 dolichyl-phosphate beta-glucosyltransferase.	0.958
Dolk	dpagt1	ENSPREP00000001501	ENSPREP00000033876	Dolichol kinase.	Uncharacterized protein.	0.955
Dolk	dpm2	ENSPREP00000001501	ENSPREP00000011031	Dolichol kinase.	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family.	0.970
Dolk	dpm3	ENSPREP00000001501	ENSPREP00000028960	Dolichol kinase.	Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family.	0.959
ENSPREP00000018226	alg1	ENSPREP00000018226	ENSPREP00000020074	NAD(P)-bd_dom domain-containing protein.	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.	0.599
ENSPREP00000018226	alg5	ENSPREP00000018226	ENSPREP00000017135	NAD(P)-bd_dom domain-containing protein.	ALG5 dolichyl-phosphate beta-glucosyltransferase.	0.528
ENSPREP00000018226	dpagt1	ENSPREP00000018226	ENSPREP00000033876	NAD(P)-bd_dom domain-containing protein.	Uncharacterized protein.	0.715
LOC103473139	alg1	ENSPREP00000008686	ENSPREP00000020074	Uncharacterized protein.	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.	0.971
LOC103473139	alg13	ENSPREP00000008686	ENSPREP00000012827	Uncharacterized protein.	Zgc:92907.	0.981
LOC103473139	alg14	ENSPREP00000008686	ENSPREP00000008188	Uncharacterized protein.	ALG14 UDP-N-acetylglucosaminyltransferase subunit.	0.992
LOC103473139	alg5	ENSPREP00000008686	ENSPREP00000017135	Uncharacterized protein.	ALG5 dolichyl-phosphate beta-glucosyltransferase.	0.453
LOC103473139	dpagt1	ENSPREP00000008686	ENSPREP00000033876	Uncharacterized protein.	Uncharacterized protein.	0.982
LOC103473139	dpm2	ENSPREP00000008686	ENSPREP00000011031	Uncharacterized protein.	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family.	0.549
alg1	Dolk	ENSPREP00000020074	ENSPREP00000001501	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.	Dolichol kinase.	0.727
alg1	ENSPREP00000018226	ENSPREP00000020074	ENSPREP00000018226	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.	NAD(P)-bd_dom domain-containing protein.	0.599
alg1	LOC103473139	ENSPREP00000020074	ENSPREP00000008686	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.	Uncharacterized protein.	0.971
alg1	alg13	ENSPREP00000020074	ENSPREP00000012827	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.	Zgc:92907.	0.978
alg1	alg14	ENSPREP00000020074	ENSPREP00000008188	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.	ALG14 UDP-N-acetylglucosaminyltransferase subunit.	0.969
alg1	alg5	ENSPREP00000020074	ENSPREP00000017135	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.	ALG5 dolichyl-phosphate beta-glucosyltransferase.	0.771

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.871

expected number of edges:

10

PPI enrichment p-value:

0.000306

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033198

Response to ATP

5 of 14

2.87

5.17

2.21e-10

GO:0032732

Positive regulation of interleukin-1 production

4 of 34

2.39

2.96

1.91e-06

GO:0035590

Purinergic nucleotide receptor signaling pathway

4 of 36

2.36

2.93

2.13e-06

GO:0006812

Cation transport

11 of 975

1.37

2.43

7.37e-12

GO:0002931

Response to ischemia

3 of 17

2.56

2.32

4.77e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035381

ATP-gated ion channel activity

3 of 9

2.84

2.91

4.43e-06

GO:0005261

Cation channel activity

8 of 469

1.55

2.69

2.02e-09

GO:0015267

Channel activity

9 of 648

1.46

2.54

3.54e-10

GO:0008324

Cation transmembrane transporter activity

10 of 823

1.4

2.42

1.11e-10

GO:0001614

Purinergic nucleotide receptor activity

3 of 23

2.43

2.31

4.41e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005639

Integral component of nuclear inner membrane

3 of 12

2.72

2.35

4.73e-05

GO:0005921

Gap junction

3 of 43

2.16

1.91

0.00020

GO:0005911

Cell-cell junction

4 of 389

1.33

0.99

0.0036

GO:0030054

Cell junction

6 of 1752

0.85

0.59

0.0082

GO:0120025

Plasma membrane bounded cell projection

6 of 1857

0.83

0.57

0.0091

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:43862

Nucleotide receptor activity, and TMEM119 family

7 of 24

2.78

7.35

6.66e-15

CL:43865

ATP P2X receptor, and Innexin

5 of 10

3.02

5.6

4.43e-11

CL:43868

ATP P2X receptor

2 of 5

2.92

1.25

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04621

NOD-like receptor signaling pathway

3 of 133

1.67

1.09

0.0054

pret04020

Calcium signaling pathway

3 of 250

1.4

0.8

0.0172

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112307

Transmission across Electrical Synapses

3 of 10

2.79

2.4

3.93e-05

MAP-112303

Electric Transmission Across Gap Junctions

3 of 10

2.79

2.4

3.93e-05

MAP-139853

Elevation of cytosolic Ca2+ levels

3 of 21

2.47

2.16

9.24e-05

MAP-844456

The NLRP3 inflammasome

3 of 27

2.36

2.04

0.00014

MAP-9730628

Sensory perception of salty taste

2 of 2

3.32

1.96

0.00030

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005639

Integral component of nuclear inner membrane

3 of 11

2.75

2.36

4.60e-05

GOCC:0005921

Gap junction

3 of 38

2.21

1.8

0.00035

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0407

Ion channel

6 of 308

1.61

2.26

9.31e-07

KW-0303

Gap junction

3 of 41

2.18

2.16

5.96e-05

KW-0325

Glycoprotein

3 of 61

2.01

1.91

0.00014

KW-1071

Ligand-gated ion channel

2 of 63

1.82

0.94

0.0144

KW-1133

Transmembrane helix

11 of 5706

0.6

0.54

2.64e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00876

Innexin

3 of 4

3.19

2.86

6.58e-06

PF00864

ATP P2X receptor

3 of 7

2.95

2.71

1.13e-05

PF14798

Calcium homeostasis modulator

2 of 5

2.92

1.37

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039099

Pannexin

3 of 4

3.19

2.59

2.05e-05

IPR000990

Innexin

3 of 4

3.19

2.59

2.05e-05

IPR027309

P2X purinoreceptor extracellular domain superfamily

3 of 7

2.95

2.54

2.35e-05

IPR001429

P2X purinoreceptor

3 of 7

2.95

2.54

2.35e-05

IPR029569

Calcium homeostasis modulator family

2 of 5

2.92

1.22

0.0063

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