ENSPREP00000033991 protein (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSPREP00000033991

Uncharacterized protein. (87 aa)

Predicted Functional Partners:

grb2

0.675

CDC42

0.650

LOC103465423

0.650

sh3rf3

0.569

LOC103472837

0.530

LOC103477993

0.530

LOC103477991

0.530

nck2

0.454

nck1

0.454

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ENSPREP00000033991	ENSPREP00000005959	ENSPREP00000033991	Cell division cycle 42.	Uncharacterized protein.	0.650
CDC42	LOC103472837	ENSPREP00000005959	ENSPREP00000001820	Cell division cycle 42.	Uncharacterized protein.	0.900
CDC42	LOC103477991	ENSPREP00000005959	ENSPREP00000017385	Cell division cycle 42.	Uncharacterized protein.	0.901
CDC42	grb2	ENSPREP00000005959	ENSPREP00000022510	Cell division cycle 42.	Growth factor receptor-bound protein 2b.	0.669
CDC42	nck1	ENSPREP00000005959	ENSPREP00000031849	Cell division cycle 42.	Cytoplasmic protein.	0.588
CDC42	nck2	ENSPREP00000005959	ENSPREP00000013658	Cell division cycle 42.	Cytoplasmic protein.	0.588
CDC42	sh3rf3	ENSPREP00000005959	ENSPREP00000018669	Cell division cycle 42.	SH3 domain containing ring finger 3.	0.575
ENSPREP00000033991	CDC42	ENSPREP00000033991	ENSPREP00000005959	Uncharacterized protein.	Cell division cycle 42.	0.650
ENSPREP00000033991	LOC103465423	ENSPREP00000033991	ENSPREP00000026666	Uncharacterized protein.	Cell division cycle 42.	0.650
ENSPREP00000033991	LOC103472837	ENSPREP00000033991	ENSPREP00000001820	Uncharacterized protein.	Uncharacterized protein.	0.530
ENSPREP00000033991	LOC103477991	ENSPREP00000033991	ENSPREP00000017385	Uncharacterized protein.	Uncharacterized protein.	0.530
ENSPREP00000033991	LOC103477993	ENSPREP00000033991	ENSPREP00000016909	Uncharacterized protein.	Uncharacterized protein.	0.530
ENSPREP00000033991	grb2	ENSPREP00000033991	ENSPREP00000022510	Uncharacterized protein.	Growth factor receptor-bound protein 2b.	0.675
ENSPREP00000033991	nck1	ENSPREP00000033991	ENSPREP00000031849	Uncharacterized protein.	Cytoplasmic protein.	0.454
ENSPREP00000033991	nck2	ENSPREP00000033991	ENSPREP00000013658	Uncharacterized protein.	Cytoplasmic protein.	0.454
ENSPREP00000033991	sh3rf3	ENSPREP00000033991	ENSPREP00000018669	Uncharacterized protein.	SH3 domain containing ring finger 3.	0.569
LOC103465423	ENSPREP00000033991	ENSPREP00000026666	ENSPREP00000033991	Cell division cycle 42.	Uncharacterized protein.	0.650
LOC103465423	grb2	ENSPREP00000026666	ENSPREP00000022510	Cell division cycle 42.	Growth factor receptor-bound protein 2b.	0.669
LOC103465423	nck1	ENSPREP00000026666	ENSPREP00000031849	Cell division cycle 42.	Cytoplasmic protein.	0.588
LOC103465423	nck2	ENSPREP00000026666	ENSPREP00000013658	Cell division cycle 42.	Cytoplasmic protein.	0.588

page 1 of 4

Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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