kif20a protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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kif20a

Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (885 aa)

Predicted Functional Partners:

LOC103464955

0.826

LOC103460746

0.826

racgap1

0.826

kif11

0.784

ENSPREP00000023746

0.684

PLK1

0.679

plk3

0.679

plk2

0.679

KIF18A

0.651

LOC103463131

0.651

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000023746	KIF18A	ENSPREP00000023746	ENSPREP00000033468	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.950
ENSPREP00000023746	LOC103460746	ENSPREP00000023746	ENSPREP00000010051	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Si:ch1073-416j23.1.	0.678
ENSPREP00000023746	LOC103463131	ENSPREP00000023746	ENSPREP00000033737	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Abnormal spindle microtubule assembly.	0.936
ENSPREP00000023746	LOC103464955	ENSPREP00000023746	ENSPREP00000001584	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.678
ENSPREP00000023746	PLK1	ENSPREP00000023746	ENSPREP00000000056	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Serine/threonine-protein kinase PLK.	0.784
ENSPREP00000023746	kif11	ENSPREP00000023746	ENSPREP00000017489	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.981
ENSPREP00000023746	kif20a	ENSPREP00000023746	ENSPREP00000034189	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.684
ENSPREP00000023746	plk2	ENSPREP00000023746	ENSPREP00000026562	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Serine/threonine-protein kinase PLK.	0.784
ENSPREP00000023746	plk3	ENSPREP00000023746	ENSPREP00000003181	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Serine/threonine-protein kinase PLK.	0.784
ENSPREP00000023746	racgap1	ENSPREP00000023746	ENSPREP00000033308	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Rac GTPase activating protein 1.	0.678
KIF18A	ENSPREP00000023746	ENSPREP00000033468	ENSPREP00000023746	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.950
KIF18A	LOC103460746	ENSPREP00000033468	ENSPREP00000010051	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Si:ch1073-416j23.1.	0.692
KIF18A	LOC103463131	ENSPREP00000033468	ENSPREP00000033737	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Abnormal spindle microtubule assembly.	0.818
KIF18A	LOC103464955	ENSPREP00000033468	ENSPREP00000001584	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.692
KIF18A	PLK1	ENSPREP00000033468	ENSPREP00000000056	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Serine/threonine-protein kinase PLK.	0.745
KIF18A	kif11	ENSPREP00000033468	ENSPREP00000017489	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.976
KIF18A	kif20a	ENSPREP00000033468	ENSPREP00000034189	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.651
KIF18A	plk2	ENSPREP00000033468	ENSPREP00000026562	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Serine/threonine-protein kinase PLK.	0.745
KIF18A	plk3	ENSPREP00000033468	ENSPREP00000003181	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Serine/threonine-protein kinase PLK.	0.745
KIF18A	racgap1	ENSPREP00000033468	ENSPREP00000033308	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Rac GTPase activating protein 1.	0.692

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Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.768

expected number of edges:

10

PPI enrichment p-value:

0.000164

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1901621

Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

3 of 5

3.1

2.44

3.76e-05

GO:0019934

cGMP-mediated signaling

3 of 11

2.75

2.35

4.88e-05

GO:0010737

Protein kinase A signaling

3 of 12

2.72

2.33

5.08e-05

GO:0070613

Regulation of protein processing

3 of 40

2.19

1.72

0.00051

GO:0001843

Neural tube closure

3 of 43

2.16

1.69

0.00056

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004690

Cyclic nucleotide-dependent protein kinase activity

6 of 15

2.92

6.63

3.38e-13

GO:0004691

cAMP-dependent protein kinase activity

3 of 6

3.02

2.86

6.20e-06

GO:0004692

cGMP-dependent protein kinase activity

3 of 7

2.95

2.84

6.65e-06

GO:0004679

AMP-activated protein kinase activity

3 of 7

2.95

2.84

6.65e-06

GO:0004383

Guanylate cyclase activity

3 of 16

2.59

2.5

2.26e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008074

Guanylate cyclase complex, soluble

3 of 3

3.32

3.14

2.08e-06

GO:0097546

Ciliary base

3 of 25

2.4

2.0

0.00017

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:38343157

(2024) Identification of Philaster apodigitiformis in aquaculture and functional characterization of its beta-PKA gene and expression analysis of infected Poecilia reticulata.

3 of 4

3.19

3.1

2.38e-06

PMID:29491911

(2016) Biochemical regulation of pigment motility in vertebrate chromatophores: a review of physiological color change mechanisms.

3 of 5

3.1

3.09

2.38e-06

PMID:29104539

(2017) Annonaceae: Breaking the Wall of Inflammation.

3 of 9

2.84

2.89

4.98e-06

PMID:36430661

(2022) Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation.

3 of 22

2.45

2.34

3.89e-05

PMID:27571066

(2016) Sexually Dimorphic Gene Expression Associated with Growth and Reproduction of Tongue Sole (Cynoglossus semilaevis) Revealed by Brain Transcriptome Analysis.

3 of 26

2.38

2.27

4.94e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26061

Cyclic nucleotide-dependent protein kinase activity, and PKA activation in glucagon signalling

10 of 33

2.8

11.47

9.79e-24

CL:26104

cGMP-dependent protein kinase activity, and Heme NO-binding

6 of 10

3.1

7.4

1.86e-14

CL:26106

Heme NO-binding, and cGMP-dependent protein kinase activity

5 of 5

3.32

6.43

1.86e-12

CL:26063

PKA activation in glucagon signalling, and Hormone-sensitive lipase, N-terminal

4 of 20

2.62

3.53

2.19e-07

CL:26065

PKA activation in glucagon signalling, and Hormone-sensitive lipase, N-terminal

3 of 11

2.75

2.57

1.88e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04540

Gap junction

9 of 103

2.26

7.25

1.06e-17

pret04270

Vascular smooth muscle contraction

7 of 128

2.06

4.74

5.74e-12

pret04340

Hedgehog signaling pathway

3 of 53

2.07

1.96

0.00013

pret04914

Progesterone-mediated oocyte maturation

3 of 88

1.85

1.63

0.00041

pret04912

GnRH signaling pathway

3 of 94

1.82

1.62

0.00041

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-392517

Rap1 signalling

4 of 30

2.44

2.96

2.22e-06

MAP-164378

PKA activation in glucagon signalling

3 of 12

2.72

2.45

3.12e-05

MAP-442720

CREB1 phosphorylation through the activation of Adenylate Cyclase

3 of 13

2.68

2.44

3.12e-05

MAP-163359

Glucagon signaling in metabolic regulation

3 of 13

2.68

2.44

3.12e-05

MAP-418457

cGMP effects

3 of 18

2.54

2.41

3.12e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008074

Guanylate cyclase complex, soluble

3 of 4

3.19

2.95

4.43e-06

GOCC:0048471

Perinuclear region of cytoplasm

3 of 66

1.98

1.28

0.0033

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

6 of 233

1.73

2.75

9.04e-08

KW-0456

Lyase

3 of 71

1.94

1.74

0.00029

KW-0547

Nucleotide-binding

9 of 1223

1.18

1.58

6.19e-08

KW-0067

ATP-binding

6 of 940

1.12

1.09

0.00016

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07700

Haem-NO-binding

3 of 3

3.32

3.0

3.76e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042463

Haem NO binding associated domain superfamily

3 of 3

3.32

2.73

1.17e-05

IPR038158

H-NOX domain superfamily

3 of 3

3.32

2.73

1.17e-05

IPR011644

Heme NO-binding

3 of 3

3.32

2.73

1.17e-05

IPR044109

cAMP-dependent protein kinase catalytic subunit

3 of 4

3.19

2.72

1.17e-05

IPR011645

Haem NO binding associated

3 of 4

3.19

2.72

1.17e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00133

Extension to Ser/Thr-type protein kinases

4 of 63

2.12

2.38

1.70e-05

SM00044

Adenylyl- / guanylyl cyclase, catalytic domain

3 of 31

2.3

2.04

0.00013

SM00220

Serine/Threonine protein kinases, catalytic domain

5 of 273

1.58

1.77

4.33e-05

SM00100

Cyclic nucleotide-monophosphate binding domain

2 of 48

1.94

0.69

0.0494

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