STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
erbb3Protein kinase domain-containing protein. (1413 aa)    
Predicted Functional Partners:
grb2
Growth factor receptor-bound protein 2b.
    
 0.980
SHC4
SHC adaptor protein 4.
    
 0.966
shc1
SHC (Src homology 2 domain containing) transforming protein 1.
    
 0.966
SHC3
SHC adaptor protein 3.
    
 0.966
LOC102218549
Neuregulin 2a.
    
 0.965
LOC102236685
Neuregulin 2b.
    
 0.965
LOC102216631
SHC (Src homology 2 domain containing) transforming protein 2.
    
 0.959
LOC102225708
Erb-b2 receptor tyrosine kinase 3b.
  
  
0.904
tgfa
Transforming growth factor, alpha.
    
 0.888
erbb2
Receptor protein-tyrosine kinase.
  
  
0.855
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.