STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fan1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (945 aa)    
Predicted Functional Partners:
fancm
Uncharacterized protein.
    
 0.985
mlh1
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).
   
 0.984
pms2
PMS1 homolog 2, mismatch repair system component.
   
 0.968
fancd2
FA complementation group D2.
    
 0.936
fanci
FA complementation group I.
    
 0.853
mus81
MUS81 structure-specific endonuclease subunit.
    
 0.829
LOC102233862
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
   
 
 0.817
dclre1a
DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae).
    
 0.798
fancl
FA complementation group L.
     
 0.789
ercc4
Excision repair cross-complementation group 4.
    
 0.781
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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