STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (342 aa)    
Predicted Functional Partners:
mdm4
MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.
   
 0.997
LOC102235592
E1A binding protein p300 b.
    
 0.990
LOC102230576
CREB binding protein b.
    
 0.990
LOC102226082
E1A binding protein p300 a.
    
 0.990
LOC102221134
CREB binding protein a.
    
 0.990
chek1
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
    
 0.986
sirt1
Sirtuin 1.
    
 0.982
mdm2
MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.
   
 0.982
prkdc
Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.
    
 0.974
atm
ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
   
 0.967
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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