| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CED72450.1 | folB | AWOD_I_2395 | AWOD_I_0353 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.584 |
| CED72450.1 | folC | AWOD_I_2395 | AWOD_I_1812 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.953 |
| CED72450.1 | folE | AWOD_I_2395 | AWOD_I_1712 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | GTP cyclohydrolase I. | 0.557 |
| CED72450.1 | folK | AWOD_I_2395 | AWOD_I_0428 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 2-amino-4-hydroxy-6-hydroxymethyl-dihydropterid ine diphosphokinase. | 0.567 |
| CED72450.1 | folP | AWOD_I_2395 | AWOD_I_0474 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.584 |
| CED72450.1 | ribD | AWOD_I_2395 | AWOD_I_0669 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Pyrimidine deaminase/pyrimidine reductase (riboflavin biosynthesis protein RibD); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.400 |
| folB | CED72450.1 | AWOD_I_0353 | AWOD_I_2395 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.584 |
| folB | folC | AWOD_I_0353 | AWOD_I_1812 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.774 |
| folB | folE | AWOD_I_0353 | AWOD_I_1712 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase I. | 0.975 |
| folB | folK | AWOD_I_0353 | AWOD_I_0428 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6-hydroxymethyl-dihydropterid ine diphosphokinase. | 0.995 |
| folB | folK-1 | AWOD_I_0353 | AWOD_I_0354 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | 0.998 |
| folB | folP | AWOD_I_0353 | AWOD_I_0474 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
| folB | plsY | AWOD_I_0353 | AWOD_I_0352 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. | 0.678 |
| folB | ribBA | AWOD_I_0353 | AWOD_I_0671 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.587 |
| folB | ribD | AWOD_I_0353 | AWOD_I_0669 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Pyrimidine deaminase/pyrimidine reductase (riboflavin biosynthesis protein RibD); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.684 |
| folB | uppP | AWOD_I_0353 | AWOD_I_0355 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.831 |
| folC | CED72450.1 | AWOD_I_1812 | AWOD_I_2395 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.953 |
| folC | folB | AWOD_I_1812 | AWOD_I_0353 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.774 |
| folC | folE | AWOD_I_1812 | AWOD_I_1712 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase I. | 0.802 |
| folC | folK | AWOD_I_1812 | AWOD_I_0428 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6-hydroxymethyl-dihydropterid ine diphosphokinase. | 0.802 |