| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gmhB | metI | AWOD_I_0648 | AWOD_I_0646 | D,D-heptose 1,7-bisphosphate phosphatase. | D-methionine transport system permease protein MetI. | 0.618 |
| gmhB | metN | AWOD_I_0648 | AWOD_I_0647 | D,D-heptose 1,7-bisphosphate phosphatase. | D-methionine transport ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.618 |
| gmhB | metQ | AWOD_I_0648 | AWOD_I_0645 | D,D-heptose 1,7-bisphosphate phosphatase. | D-methionine-binding lipoprotein MetQ precursor; Belongs to the nlpA lipoprotein family. | 0.560 |
| metA | metB | AWOD_I_2140 | AWOD_I_0335 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Cystathionine gamma-synthase (O-succinylhomoserin (thiol)-lyase). | 0.966 |
| metA | metC | AWOD_I_2140 | AWOD_I_1173 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Cystathionine beta-lyase. | 0.683 |
| metA | metF | AWOD_I_2140 | AWOD_I_0291 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.948 |
| metA | metH | AWOD_I_2140 | AWOD_I_2336 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.938 |
| metA | metI | AWOD_I_2140 | AWOD_I_0646 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | D-methionine transport system permease protein MetI. | 0.766 |
| metA | metK | AWOD_I_2140 | AWOD_I_2246 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.581 |
| metA | metN | AWOD_I_2140 | AWOD_I_0647 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | D-methionine transport ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.804 |
| metB | metA | AWOD_I_0335 | AWOD_I_2140 | Cystathionine gamma-synthase (O-succinylhomoserin (thiol)-lyase). | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.966 |
| metB | metC | AWOD_I_0335 | AWOD_I_1173 | Cystathionine gamma-synthase (O-succinylhomoserin (thiol)-lyase). | Cystathionine beta-lyase. | 0.923 |
| metB | metF | AWOD_I_0335 | AWOD_I_0291 | Cystathionine gamma-synthase (O-succinylhomoserin (thiol)-lyase). | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.783 |
| metB | metH | AWOD_I_0335 | AWOD_I_2336 | Cystathionine gamma-synthase (O-succinylhomoserin (thiol)-lyase). | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.977 |
| metB | metJ | AWOD_I_0335 | AWOD_I_0334 | Cystathionine gamma-synthase (O-succinylhomoserin (thiol)-lyase). | Met repressor (Met regulon regulatory protein MetJ); This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. | 0.773 |
| metB | metN | AWOD_I_0335 | AWOD_I_0647 | Cystathionine gamma-synthase (O-succinylhomoserin (thiol)-lyase). | D-methionine transport ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.515 |
| metC | metA | AWOD_I_1173 | AWOD_I_2140 | Cystathionine beta-lyase. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.683 |
| metC | metB | AWOD_I_1173 | AWOD_I_0335 | Cystathionine beta-lyase. | Cystathionine gamma-synthase (O-succinylhomoserin (thiol)-lyase). | 0.923 |
| metC | metF | AWOD_I_1173 | AWOD_I_0291 | Cystathionine beta-lyase. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.766 |
| metC | metH | AWOD_I_1173 | AWOD_I_2336 | Cystathionine beta-lyase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.977 |