| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MVIS_3437 | MVIS_3467 | MVIS_3437 | MVIS_3467 | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.904 |
| MVIS_3437 | cysE | MVIS_3437 | MVIS_0174 | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine acetyltransferase. | 0.930 |
| MVIS_3437 | glyA | MVIS_3437 | MVIS_3744 | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.968 |
| MVIS_3437 | ilvA | MVIS_3437 | MVIS_4367 | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.928 |
| MVIS_3437 | metL | MVIS_3437 | MVIS_4312 | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Bifunctional aspartokinase/homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.831 |
| MVIS_3437 | serB | MVIS_3437 | MVIS_3796 | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Phosphoserine phosphatase. | 0.912 |
| MVIS_3437 | thrA | MVIS_3437 | MVIS_0829 | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Bifunctional aspartokinase/homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.831 |
| MVIS_3467 | MVIS_3437 | MVIS_3467 | MVIS_3437 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.904 |
| MVIS_3467 | cysE | MVIS_3467 | MVIS_0174 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine acetyltransferase. | 0.930 |
| MVIS_3467 | glyA | MVIS_3467 | MVIS_3744 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.968 |
| MVIS_3467 | ilvA | MVIS_3467 | MVIS_4367 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.928 |
| MVIS_3467 | metL | MVIS_3467 | MVIS_4312 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Bifunctional aspartokinase/homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.831 |
| MVIS_3467 | serB | MVIS_3467 | MVIS_3796 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Phosphoserine phosphatase. | 0.912 |
| MVIS_3467 | thrA | MVIS_3467 | MVIS_0829 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Bifunctional aspartokinase/homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.831 |
| cysE | MVIS_3437 | MVIS_0174 | MVIS_3437 | Serine acetyltransferase. | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.930 |
| cysE | MVIS_3467 | MVIS_0174 | MVIS_3467 | Serine acetyltransferase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.930 |
| cysE | cysK | MVIS_0174 | MVIS_1219 | Serine acetyltransferase. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.999 |
| cysE | cysS | MVIS_0174 | MVIS_3039 | Serine acetyltransferase. | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.984 |
| cysE | glyA | MVIS_0174 | MVIS_3744 | Serine acetyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.854 |
| cysE | gpsA | MVIS_0174 | MVIS_4269 | Serine acetyltransferase. | Glycerol-3-phosphate dehydrogenase [NAD(P)+]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.843 |