| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MVIS_0186 | MVIS_2278 | MVIS_0186 | MVIS_2278 | Cys/Met metabolism PLP-dependent enzyme. | Pyridine nucleotide-disulphide oxidoreductase. | 0.648 |
| MVIS_0186 | cysD | MVIS_0186 | MVIS_0613 | Cys/Met metabolism PLP-dependent enzyme. | Sulfate adenylyltransferase subunit 2. | 0.621 |
| MVIS_0186 | fadH | MVIS_0186 | MVIS_0678 | Cys/Met metabolism PLP-dependent enzyme. | 2,4-dienoyl-CoA reductase. | 0.659 |
| MVIS_0186 | metE | MVIS_0186 | MVIS_1643 | Cys/Met metabolism PLP-dependent enzyme. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.940 |
| MVIS_0186 | metH | MVIS_0186 | MVIS_4156 | Cys/Met metabolism PLP-dependent enzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.966 |
| MVIS_0186 | metK | MVIS_0186 | MVIS_3597 | Cys/Met metabolism PLP-dependent enzyme. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.929 |
| MVIS_0186 | metQ | MVIS_0186 | MVIS_0621 | Cys/Met metabolism PLP-dependent enzyme. | D-methionine-binding lipoprotein MetQ precursor; Belongs to the nlpA lipoprotein family. | 0.810 |
| MVIS_2278 | MVIS_0186 | MVIS_2278 | MVIS_0186 | Pyridine nucleotide-disulphide oxidoreductase. | Cys/Met metabolism PLP-dependent enzyme. | 0.648 |
| MVIS_2278 | cysD | MVIS_2278 | MVIS_0613 | Pyridine nucleotide-disulphide oxidoreductase. | Sulfate adenylyltransferase subunit 2. | 0.536 |
| MVIS_2278 | metH | MVIS_2278 | MVIS_4156 | Pyridine nucleotide-disulphide oxidoreductase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.539 |
| MVIS_2278 | metQ | MVIS_2278 | MVIS_0621 | Pyridine nucleotide-disulphide oxidoreductase. | D-methionine-binding lipoprotein MetQ precursor; Belongs to the nlpA lipoprotein family. | 0.515 |
| cysD | MVIS_0186 | MVIS_0613 | MVIS_0186 | Sulfate adenylyltransferase subunit 2. | Cys/Met metabolism PLP-dependent enzyme. | 0.621 |
| cysD | MVIS_2278 | MVIS_0613 | MVIS_2278 | Sulfate adenylyltransferase subunit 2. | Pyridine nucleotide-disulphide oxidoreductase. | 0.536 |
| cysD | metQ | MVIS_0613 | MVIS_0621 | Sulfate adenylyltransferase subunit 2. | D-methionine-binding lipoprotein MetQ precursor; Belongs to the nlpA lipoprotein family. | 0.550 |
| fadH | MVIS_0186 | MVIS_0678 | MVIS_0186 | 2,4-dienoyl-CoA reductase. | Cys/Met metabolism PLP-dependent enzyme. | 0.659 |
| fadH | metQ | MVIS_0678 | MVIS_0621 | 2,4-dienoyl-CoA reductase. | D-methionine-binding lipoprotein MetQ precursor; Belongs to the nlpA lipoprotein family. | 0.513 |
| metE | MVIS_0186 | MVIS_1643 | MVIS_0186 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Cys/Met metabolism PLP-dependent enzyme. | 0.940 |
| metE | metF-2 | MVIS_1643 | MVIS_4311 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.956 |
| metE | metH | MVIS_1643 | MVIS_4156 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.988 |
| metE | metK | MVIS_1643 | MVIS_3597 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.988 |