| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MVIS_2376 | queE | MVIS_2376 | MVIS_2374 | Putative effector of murein hydrolase, LrgB family. | Radical SAM superfamily protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.545 |
| MVIS_3058 | folE | MVIS_3058 | MVIS_1602 | Putative uncharacterized protein. | GTP cyclohydrolase I. | 0.780 |
| MVIS_3058 | queC | MVIS_3058 | MVIS_1407 | Putative uncharacterized protein. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.942 |
| MVIS_3058 | queE | MVIS_3058 | MVIS_2374 | Putative uncharacterized protein. | Radical SAM superfamily protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.881 |
| MVIS_3058 | queF | MVIS_3058 | MVIS_3865 | Putative uncharacterized protein. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.935 |
| MVIS_3933 | queE | MVIS_3933 | MVIS_2374 | Putative uncharacterized protein. | Radical SAM superfamily protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.544 |
| folE | MVIS_3058 | MVIS_1602 | MVIS_3058 | GTP cyclohydrolase I. | Putative uncharacterized protein. | 0.780 |
| folE | nrdD | MVIS_1602 | MVIS_1392 | GTP cyclohydrolase I. | Anaerobic ribonucleoside-triphosphate reductase. | 0.800 |
| folE | queA | MVIS_1602 | MVIS_0781 | GTP cyclohydrolase I. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.448 |
| folE | queC | MVIS_1602 | MVIS_1407 | GTP cyclohydrolase I. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.567 |
| folE | queE | MVIS_1602 | MVIS_2374 | GTP cyclohydrolase I. | Radical SAM superfamily protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.641 |
| folE | queF | MVIS_1602 | MVIS_3865 | GTP cyclohydrolase I. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.592 |
| folE | queG | MVIS_1602 | MVIS_0395 | GTP cyclohydrolase I. | Putative ferredoxin, 4Fe-4S binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. | 0.515 |
| nadA | queE | MVIS_3076 | MVIS_2374 | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | Radical SAM superfamily protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.576 |
| nrdD | folE | MVIS_1392 | MVIS_1602 | Anaerobic ribonucleoside-triphosphate reductase. | GTP cyclohydrolase I. | 0.800 |
| nrdD | queE | MVIS_1392 | MVIS_2374 | Anaerobic ribonucleoside-triphosphate reductase. | Radical SAM superfamily protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.882 |
| queA | folE | MVIS_0781 | MVIS_1602 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | GTP cyclohydrolase I. | 0.448 |
| queA | queC | MVIS_0781 | MVIS_1407 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.621 |
| queA | queE | MVIS_0781 | MVIS_2374 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Radical SAM superfamily protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.549 |
| queA | queF | MVIS_0781 | MVIS_3865 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.687 |