STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
piezo1Piezo-type mechanosensitive ion channel component. (2274 aa)    
Predicted Functional Partners:
tipin
TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.
   
 
 0.803
timeless
Timeless circadian clock.
    
 
 0.789
mcm4
DNA helicase; Belongs to the MCM family.
   
 0.784
wdhd1
WD repeat and HMG-box DNA binding protein 1.
   
 
 0.779
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae).
    
 0.772
chek2
Checkpoint kinase 2.
    
 
 0.766
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
   
 
 0.722
tp53bp1
Tumor protein p53 binding protein, 1.
    
 
 0.701
cdc6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.683
mcm2
DNA helicase; Belongs to the MCM family.
   
 0.680
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.