H2L587_ORYLA protein (Oryzias latipes) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

H2L587_ORYLA

DUF3480 domain-containing protein. (297 aa)

Predicted Functional Partners:

LOC101169523

0.962

LOC101159109

0.962

LOC101173779

0.903

Zfyve9

0.900

smad3

0.636

smad2

0.636

TGFBR2

0.587

ptpn23

0.586

SMAD4

0.583

LOC101173916

0.583

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2L587_ORYLA	LOC101159109	ENSORLP00000000954	ENSORLP00000019646	DUF3480 domain-containing protein.	Mothers against decapentaplegic homolog.	0.962
H2L587_ORYLA	LOC101169523	ENSORLP00000000954	ENSORLP00000002748	DUF3480 domain-containing protein.	Mothers against decapentaplegic homolog.	0.962
H2L587_ORYLA	LOC101173779	ENSORLP00000000954	ENSORLP00000020669	DUF3480 domain-containing protein.	Zinc finger, FYVE domain containing 9b.	0.903
H2L587_ORYLA	LOC101173916	ENSORLP00000000954	ENSORLP00000029700	DUF3480 domain-containing protein.	Mothers against decapentaplegic homolog.	0.583
H2L587_ORYLA	SMAD4	ENSORLP00000000954	ENSORLP00000006328	DUF3480 domain-containing protein.	Mothers against decapentaplegic homolog.	0.583
H2L587_ORYLA	TGFBR2	ENSORLP00000000954	ENSORLP00000041955	DUF3480 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.587
H2L587_ORYLA	Zfyve9	ENSORLP00000000954	ENSORLP00000035073	DUF3480 domain-containing protein.	SARA domain-containing protein.	0.900
H2L587_ORYLA	ptpn23	ENSORLP00000000954	ENSORLP00000038124	DUF3480 domain-containing protein.	Protein tyrosine phosphatase, non-receptor type 23, a.	0.586
H2L587_ORYLA	smad2	ENSORLP00000000954	ENSORLP00000014831	DUF3480 domain-containing protein.	Mothers against decapentaplegic homolog.	0.636
H2L587_ORYLA	smad3	ENSORLP00000000954	ENSORLP00000008548	DUF3480 domain-containing protein.	Mothers against decapentaplegic homolog.	0.636
LOC101159109	H2L587_ORYLA	ENSORLP00000019646	ENSORLP00000000954	Mothers against decapentaplegic homolog.	DUF3480 domain-containing protein.	0.962
LOC101159109	LOC101169523	ENSORLP00000019646	ENSORLP00000002748	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.900
LOC101159109	LOC101173779	ENSORLP00000019646	ENSORLP00000020669	Mothers against decapentaplegic homolog.	Zinc finger, FYVE domain containing 9b.	0.950
LOC101159109	LOC101173916	ENSORLP00000019646	ENSORLP00000029700	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.979
LOC101159109	SMAD4	ENSORLP00000019646	ENSORLP00000006328	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.988
LOC101159109	TGFBR2	ENSORLP00000019646	ENSORLP00000041955	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.978
LOC101159109	Zfyve9	ENSORLP00000019646	ENSORLP00000035073	Mothers against decapentaplegic homolog.	SARA domain-containing protein.	0.962
LOC101159109	smad2	ENSORLP00000019646	ENSORLP00000014831	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.543
LOC101159109	smad3	ENSORLP00000019646	ENSORLP00000008548	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.549
LOC101169523	H2L587_ORYLA	ENSORLP00000002748	ENSORLP00000000954	Mothers against decapentaplegic homolog.	DUF3480 domain-containing protein.	0.962

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.884

expected number of edges:

13

PPI enrichment p-value:

0.035

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 114

1.48

3.0

1.12e-13

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 53

1.77

4.37

1.47e-14

GO:0019843

rRNA binding

4 of 42

1.47

1.16

0.0020

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 60

1.72

4.16

8.83e-15

GO:0015935

Small ribosomal subunit

2 of 8

1.89

1.08

0.0078

GO:0005622

Intracellular anatomical structure

11 of 1255

0.44

0.38

0.00035

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:901

Structural constituent of ribosome

10 of 57

1.74

4.17

3.15e-14

CL:980

Structural constituent of ribosome

4 of 10

2.1

2.74

2.34e-06

CL:902

rRNA-binding, and RNA polymerase

6 of 38

1.69

2.72

6.37e-08

CL:903

rRNA-binding, and Protein transport by the Sec complex

5 of 31

1.7

2.33

1.84e-06

CL:905

rRNA-binding

3 of 26

1.56

1.14

0.0032

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 58

1.73

4.26

5.36e-15

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

8 of 52

1.68

3.25

2.20e-10

GOCC:0043232

Intracellular non-membrane-bounded organelle

9 of 147

1.28

1.92

4.29e-09

GOCC:0022626

Cytosolic ribosome

3 of 22

1.63

1.22

0.0024

GOCC:0043229

Intracellular organelle

10 of 324

0.98

1.17

4.30e-08

GOCC:0044391

Ribosomal subunit

3 of 27

1.54

1.11

0.0036

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 62

1.7

4.05

1.91e-14

KW-0699

rRNA-binding

4 of 39

1.51

1.39

0.00046

KW-0820

tRNA-binding

2 of 12

1.72

0.74

0.0352

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