pak4 protein (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

pak4

Non-specific serine/threonine protein kinase. (676 aa)

Predicted Functional Partners:

nck1

0.967

nck2

0.967

CDC42

0.946

raf1

0.938

LOC101164400

0.931

map2k1

0.927

LOC101161831

0.920

LOC110015484

0.915

LOC101164658

0.867

LOC101174454

0.867

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	LOC101161831	ENSORLP00000015084	ENSORLP00000045430	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.410
CDC42	nck1	ENSORLP00000015084	ENSORLP00000012449	Cell division cycle 42.	Cytoplasmic protein.	0.672
CDC42	nck2	ENSORLP00000015084	ENSORLP00000039494	Cell division cycle 42.	Cytoplasmic protein.	0.672
CDC42	pak4	ENSORLP00000015084	ENSORLP00000001862	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.946
LOC101161831	CDC42	ENSORLP00000045430	ENSORLP00000015084	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Cell division cycle 42.	0.410
LOC101161831	LOC101164400	ENSORLP00000045430	ENSORLP00000034529	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Uncharacterized protein.	0.410
LOC101161831	LOC110015484	ENSORLP00000045430	ENSORLP00000040688	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.902
LOC101161831	pak4	ENSORLP00000045430	ENSORLP00000001862	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Non-specific serine/threonine protein kinase.	0.920
LOC101164400	LOC101161831	ENSORLP00000034529	ENSORLP00000045430	Uncharacterized protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.410
LOC101164400	nck1	ENSORLP00000034529	ENSORLP00000012449	Uncharacterized protein.	Cytoplasmic protein.	0.672
LOC101164400	nck2	ENSORLP00000034529	ENSORLP00000039494	Uncharacterized protein.	Cytoplasmic protein.	0.672
LOC101164400	pak4	ENSORLP00000034529	ENSORLP00000001862	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.931
LOC101164658	nck1	ENSORLP00000007959	ENSORLP00000012449	Uncharacterized protein.	Cytoplasmic protein.	0.580
LOC101164658	nck2	ENSORLP00000007959	ENSORLP00000039494	Uncharacterized protein.	Cytoplasmic protein.	0.580
LOC101164658	pak4	ENSORLP00000007959	ENSORLP00000001862	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.867
LOC101174454	nck1	ENSORLP00000028896	ENSORLP00000012449	Uncharacterized protein.	Cytoplasmic protein.	0.580
LOC101174454	nck2	ENSORLP00000028896	ENSORLP00000039494	Uncharacterized protein.	Cytoplasmic protein.	0.580
LOC101174454	pak4	ENSORLP00000028896	ENSORLP00000001862	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.867
LOC110015484	LOC101161831	ENSORLP00000040688	ENSORLP00000045430	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.902
LOC110015484	pak4	ENSORLP00000040688	ENSORLP00000001862	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Non-specific serine/threonine protein kinase.	0.915