Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
nr3c1Glucocorticoid receptor GR1a. (793 aa)    
Predicted Functional Partners:
nr3c2
Mineralocorticoid receptor.
    
0.928
LOC101157675
Peptidylprolyl isomerase.
    
 0.928
nrip1
Nuclear receptor interacting protein 1b.
   
 0.916
med1
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.915
fkbp4
Peptidylprolyl isomerase.
    
 0.909
stip1
Stress-induced phosphoprotein 1.
    
 0.909
LOC100302444
Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).
  
  
 
0.903
LOC101169506
Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.
    
 0.892
hsp90ab1
Heat shock protein 90, alpha (cytosolic), class B member 1.
    
 0.892
ptges3
Prostaglandin E synthase 3b (cytosolic).
   
 0.888
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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