Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
pou4f3POU domain protein. (360 aa)    
Predicted Functional Partners:
atoh1
Atonal bHLH transcription factor 1a.
    
 
 0.809
LOC101163349
Retinal outer segment membrane protein 1a.
      
 0.692
LOC101174167
Si:dkeyp-86f7.4.
      
 0.624
LOC101171662
PNPLA domain-containing protein.
      
 0.619
ift88
Intraflagellar transport 88 homolog.
      
 0.596
LOC101175327
Atonal bHLH transcription factor 1b.
    
 
 0.590
atoh7
Atonal bHLH transcription factor 7.
    
 
 0.584
prph2
Peripherin 2a (retinal degeneration, slow).
      
 0.584
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
     
 0.580
sox10
SRY-box containing gene 10b.
   
 
 0.544
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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