Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
USP24Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family. (2596 aa)    
Predicted Functional Partners:
ddb2
Damage-specific DNA binding protein 2.
    
 0.990
pcsk2
Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family.
      
 0.907
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
    
 0.872
trip12
Thyroid hormone receptor interactor 12.
   
 
 0.841
ubc
Ubiquitin B.
    
  0.839
egf
Epidermal growth factor.
      
 0.750
bsnd
Uncharacterized protein.
      
 0.714
pcsk7
Proprotein convertase subtilisin/kexin type 7; Belongs to the peptidase S8 family.
      
 0.710
pcsk1
Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.
      
 0.708
LOC101161187
P/Homo B domain-containing protein; Belongs to the peptidase S8 family.
      
 0.708
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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