STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101160237Activity-dependent neuroprotector homeobox b. (1048 aa)    
Predicted Functional Partners:
trip12
Thyroid hormone receptor interactor 12.
   
  
 0.725
chd8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
   
 
 0.584
H2MK72_ORYLA
Uncharacterized protein.
   
  
 0.514
BPTF
Bromodomain PHD finger transcription factor.
   
  
 0.514
LOC101155276
Bromodomain PHD finger transcription factor.
   
  
 0.514
mphosph8
Uncharacterized protein.
    
 
 0.507
LOC101161417
Ash1 (absent, small, or homeotic)-like (Drosophila).
   
  
 0.496
ash1l
Uncharacterized protein.
   
  
 0.496
INSC
INSC spindle orientation adaptor protein.
      
 0.489
setd2
SET domain containing 2, histone lysine methyltransferase.
   
  
 0.483
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.