Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cyp17a2Cytochrome P450 family 17 polypeptide 2; Belongs to the cytochrome P450 family. (521 aa)    
Predicted Functional Partners:
3bhsd
3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.
   
 0.968
hsd17b3
Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.965
hsd17b1
Hydroxysteroid (17-beta) dehydrogenase 1.
   
 
 0.958
cyp11b
Cytochrome P450 11beta; Belongs to the cytochrome P450 family.
  
0.958
LOC101174651
Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
  
0.951
cyp11a
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
  
0.950
LOC101165994
20beta-hydroxysteroid dehydrogenase type2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.950
hsd17b8
Hydroxysteroid (17-beta) dehydrogenase 8.
   
 
 0.949
cyp19b
Aromatase B; Belongs to the cytochrome P450 family.
  
0.948
LOC101163971
Hydroxysteroid (17-beta) dehydrogenase 12a; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.944
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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