Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rbbp8nlRetinoblastoma binding protein 8-like. (568 aa)    
Predicted Functional Partners:
cdk5
Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.
    
 0.831
fibp
Fibroblast growth factor (acidic) intracellular binding protein a.
    
 
 0.634
DLK1
Delta like non-canonical Notch ligand 1.
    
   0.602
ccne2
Cyclin E2; Belongs to the cyclin family.
    
 0.548
ccne1
Cyclin E1; Belongs to the cyclin family.
    
 0.548
ccna1
Cyclin A1; Belongs to the cyclin family.
     
 0.541
ccna2
Cyclin A2; Belongs to the cyclin family.
     
 0.541
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
    
 
 0.487
cdk6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.475
cdk1
Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II. Catalytic component of MPF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
   
 0.475
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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