NCSTN protein (Oryzias latipes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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co-expression

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[Homology]

Score

NCSTN

Nicastrin. (677 aa)

Predicted Functional Partners:

psenen

0.999

LOC101159650

0.998

psen2

0.991

LOC101154844

0.991

notch1

0.933

LOC101171596

0.933

LOC101172288

0.903

APP

0.903

LOC101162450

0.815

aplp2

0.797

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	LOC101154844	ENSORLP00000038494	ENSORLP00000044855	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.894
APP	LOC101159650	ENSORLP00000038494	ENSORLP00000023040	Amyloid beta precursor protein.	APH1B gamma secretase subunit.	0.722
APP	LOC101171596	ENSORLP00000038494	ENSORLP00000042502	Amyloid beta precursor protein.	Notch receptor 1a.	0.604
APP	NCSTN	ENSORLP00000038494	ENSORLP00000003658	Amyloid beta precursor protein.	Nicastrin.	0.903
APP	aplp2	ENSORLP00000038494	ENSORLP00000044686	Amyloid beta precursor protein.	Amyloid beta (A4) precursor-like protein 2.	0.944
APP	notch1	ENSORLP00000038494	ENSORLP00000000793	Amyloid beta precursor protein.	Notch receptor 1b.	0.604
APP	psen2	ENSORLP00000038494	ENSORLP00000025023	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.894
APP	psenen	ENSORLP00000038494	ENSORLP00000008089	Amyloid beta precursor protein.	Presenilin enhancer, gamma-secretase subunit.	0.855
LOC101154844	APP	ENSORLP00000044855	ENSORLP00000038494	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta precursor protein.	0.894
LOC101154844	LOC101159650	ENSORLP00000044855	ENSORLP00000023040	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	APH1B gamma secretase subunit.	0.995
LOC101154844	LOC101162450	ENSORLP00000044855	ENSORLP00000044639	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Notch receptor 3.	0.824
LOC101154844	LOC101171596	ENSORLP00000044855	ENSORLP00000042502	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Notch receptor 1a.	0.914
LOC101154844	LOC101172288	ENSORLP00000044855	ENSORLP00000011186	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta (A4) precursor protein b.	0.863
LOC101154844	NCSTN	ENSORLP00000044855	ENSORLP00000003658	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Nicastrin.	0.991
LOC101154844	aplp2	ENSORLP00000044855	ENSORLP00000044686	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta (A4) precursor-like protein 2.	0.711
LOC101154844	notch1	ENSORLP00000044855	ENSORLP00000000793	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Notch receptor 1b.	0.914
LOC101154844	psen2	ENSORLP00000044855	ENSORLP00000025023	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.944
LOC101154844	psenen	ENSORLP00000044855	ENSORLP00000008089	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin enhancer, gamma-secretase subunit.	0.998
LOC101159650	APP	ENSORLP00000023040	ENSORLP00000038494	APH1B gamma secretase subunit.	Amyloid beta precursor protein.	0.722
LOC101159650	LOC101154844	ENSORLP00000023040	ENSORLP00000044855	APH1B gamma secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.995