NCSTN protein (Oryzias latipes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

NCSTN

Nicastrin. (677 aa)

Predicted Functional Partners:

psenen

0.993

LOC101159650

0.984

psen2

0.968

LOC101154844

0.968

LOC101172288

0.905

APP

0.905

notch1

0.803

LOC101171596

0.803

aplp2

0.720

LOC101170788

0.717

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	LOC101154844	ENSORLP00000038494	ENSORLP00000044855	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.727
APP	LOC101159650	ENSORLP00000038494	ENSORLP00000023040	Amyloid beta precursor protein.	APH1B gamma secretase subunit.	0.639
APP	LOC101170788	ENSORLP00000038494	ENSORLP00000007899	Amyloid beta precursor protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.598
APP	NCSTN	ENSORLP00000038494	ENSORLP00000003658	Amyloid beta precursor protein.	Nicastrin.	0.905
APP	aplp2	ENSORLP00000038494	ENSORLP00000044686	Amyloid beta precursor protein.	Amyloid beta (A4) precursor-like protein 2.	0.557
APP	psen2	ENSORLP00000038494	ENSORLP00000025023	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.727
APP	psenen	ENSORLP00000038494	ENSORLP00000008089	Amyloid beta precursor protein.	Presenilin enhancer, gamma-secretase subunit.	0.732
LOC101154844	APP	ENSORLP00000044855	ENSORLP00000038494	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta precursor protein.	0.727
LOC101154844	LOC101159650	ENSORLP00000044855	ENSORLP00000023040	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	APH1B gamma secretase subunit.	0.969
LOC101154844	LOC101171596	ENSORLP00000044855	ENSORLP00000042502	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Notch receptor 1a.	0.732
LOC101154844	LOC101172288	ENSORLP00000044855	ENSORLP00000011186	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta (A4) precursor protein b.	0.727
LOC101154844	NCSTN	ENSORLP00000044855	ENSORLP00000003658	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Nicastrin.	0.968
LOC101154844	aplp2	ENSORLP00000044855	ENSORLP00000044686	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta (A4) precursor-like protein 2.	0.628
LOC101154844	notch1	ENSORLP00000044855	ENSORLP00000000793	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Notch receptor 1b.	0.732
LOC101154844	psen2	ENSORLP00000044855	ENSORLP00000025023	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.449
LOC101154844	psenen	ENSORLP00000044855	ENSORLP00000008089	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin enhancer, gamma-secretase subunit.	0.975
LOC101159650	APP	ENSORLP00000023040	ENSORLP00000038494	APH1B gamma secretase subunit.	Amyloid beta precursor protein.	0.639
LOC101159650	LOC101154844	ENSORLP00000023040	ENSORLP00000044855	APH1B gamma secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.969
LOC101159650	LOC101171596	ENSORLP00000023040	ENSORLP00000042502	APH1B gamma secretase subunit.	Notch receptor 1a.	0.961
LOC101159650	LOC101172288	ENSORLP00000023040	ENSORLP00000011186	APH1B gamma secretase subunit.	Amyloid beta (A4) precursor protein b.	0.639