Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC101174928Coagulation factor VIII, procoagulant component; Belongs to the multicopper oxidase family. (1591 aa)    
Predicted Functional Partners:
LOC101170246
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
   
 0.949
proc
Protein C (inactivator of coagulation factors Va and VIIIa), a.
   
 0.934
pros1
Protein S.
   
 0.894
lman1
Lectin, mannose-binding, 1.
    
 0.782
mcfd2
Multiple coagulation factor deficiency 2.
     
 0.757
sspo
Subcommissural organ spondin.
    
 0.730
vwf
Von Willebrand factor.
    
 0.730
otog
Otogelin.
    
 0.730
Muc5ac
VWFD domain-containing protein.
    
 0.730
ENSORLP00000043629
Uncharacterized protein.
    
 0.730
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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