Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
msh3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1090 aa)    
Predicted Functional Partners:
msh2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
0.999
mlh1
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).
 
 0.997
pms2
PMS1 homolog 2, mismatch repair system component.
 
 0.989
pms1
PMS1 homolog 1, mismatch repair system component.
 
 0.989
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.987
snx8
Sorting nexin 8a.
    
   0.962
msh6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 
0.957
exo1
Exonuclease 1.
   
 0.932
mlh3
MutL homolog 3 (E. coli).
 
 0.923
fancm
Uncharacterized protein.
   
 
 0.898
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.