irak4 protein (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

irak4

Interleukin-1 receptor-associated kinase 4. (457 aa)

Predicted Functional Partners:

traf6

0.999

myd88

0.999

LOC101166698

0.999

tirap

0.995

tab2

0.971

tab1

0.967

LOC101154981

0.956

mavs

0.944

ikbkg

0.942

LOC101171857

0.933

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101154981	LOC101166698	ENSORLP00000032811	ENSORLP00000040412	Toll-like receptor adaptor molecule 1.	Protein kinase domain-containing protein.	0.957
LOC101154981	LOC101171857	ENSORLP00000032811	ENSORLP00000011761	Toll-like receptor adaptor molecule 1.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.624
LOC101154981	irak4	ENSORLP00000032811	ENSORLP00000003907	Toll-like receptor adaptor molecule 1.	Interleukin-1 receptor-associated kinase 4.	0.956
LOC101154981	myd88	ENSORLP00000032811	ENSORLP00000012280	Toll-like receptor adaptor molecule 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.689
LOC101154981	tab1	ENSORLP00000032811	ENSORLP00000013462	Toll-like receptor adaptor molecule 1.	TGF-beta activated kinase 1/MAP3K7 binding protein 1.	0.566
LOC101154981	tab2	ENSORLP00000032811	ENSORLP00000030054	Toll-like receptor adaptor molecule 1.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.549
LOC101154981	tirap	ENSORLP00000032811	ENSORLP00000018401	Toll-like receptor adaptor molecule 1.	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	0.652
LOC101154981	traf6	ENSORLP00000032811	ENSORLP00000001290	Toll-like receptor adaptor molecule 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.992
LOC101166698	LOC101154981	ENSORLP00000040412	ENSORLP00000032811	Protein kinase domain-containing protein.	Toll-like receptor adaptor molecule 1.	0.957
LOC101166698	LOC101171857	ENSORLP00000040412	ENSORLP00000011761	Protein kinase domain-containing protein.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.973
LOC101166698	ikbkg	ENSORLP00000040412	ENSORLP00000002636	Protein kinase domain-containing protein.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.547
LOC101166698	irak4	ENSORLP00000040412	ENSORLP00000003907	Protein kinase domain-containing protein.	Interleukin-1 receptor-associated kinase 4.	0.999
LOC101166698	mavs	ENSORLP00000040412	ENSORLP00000045913	Protein kinase domain-containing protein.	CARD_2 domain-containing protein.	0.938
LOC101166698	myd88	ENSORLP00000040412	ENSORLP00000012280	Protein kinase domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.999
LOC101166698	tab1	ENSORLP00000040412	ENSORLP00000013462	Protein kinase domain-containing protein.	TGF-beta activated kinase 1/MAP3K7 binding protein 1.	0.973
LOC101166698	tab2	ENSORLP00000040412	ENSORLP00000030054	Protein kinase domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.989
LOC101166698	tirap	ENSORLP00000040412	ENSORLP00000018401	Protein kinase domain-containing protein.	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	0.987
LOC101166698	traf6	ENSORLP00000040412	ENSORLP00000001290	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
LOC101171857	LOC101154981	ENSORLP00000011761	ENSORLP00000032811	Component of inhibitor of nuclear factor kappa B kinase complex.	Toll-like receptor adaptor molecule 1.	0.624
LOC101171857	LOC101166698	ENSORLP00000011761	ENSORLP00000040412	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.973