Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
phbProhibitin. (299 aa)    
Predicted Functional Partners:
phb2
Prohibitin.
   
 0.999
stoml2
Stomatin (EPB72)-like 2.
   
 
 0.967
e2f1
E2F transcription factor 1.
    
 
 0.939
c1qbp
Complement component 1, q subcomponent binding protein.
   
 0.932
spg7
SPG7 matrix AAA peptidase subunit, paraplegin.
   
 0.926
rb1
Retinoblastoma 1.
    
 
 0.904
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
    
 
 0.897
LOC101157690
Si:ch1073-174d20.2.
   
 0.895
afg3l2
AFG3-like AAA ATPase 2.
   
 0.895
LOC101159734
AAA domain-containing protein.
   
 0.895
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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