sqle protein (Oryzias latipes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

sqle

Squalene epoxidase a. (572 aa)

Predicted Functional Partners:

fdft1

0.999

LSS

0.997

LOC101157258

0.995

H2N0C8_ORYLA

0.992

dhcr7

0.985

hmgcs1

0.985

idi1

0.983

nsdhl

0.980

LOC100125499

0.979

msmo1

0.948

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2N0C8_ORYLA	LOC100125499	ENSORLP00000024830	ENSORLP00000021654	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.955
H2N0C8_ORYLA	LOC101157258	ENSORLP00000024830	ENSORLP00000042370	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.995
H2N0C8_ORYLA	LSS	ENSORLP00000024830	ENSORLP00000018804	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.997
H2N0C8_ORYLA	dhcr7	ENSORLP00000024830	ENSORLP00000019315	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	7-dehydrocholesterol reductase.	0.970
H2N0C8_ORYLA	fdft1	ENSORLP00000024830	ENSORLP00000021714	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	Farnesyl-diphosphate farnesyltransferase 1.	0.981
H2N0C8_ORYLA	hmgcs1	ENSORLP00000024830	ENSORLP00000031232	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.983
H2N0C8_ORYLA	idi1	ENSORLP00000024830	ENSORLP00000006292	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	Isopentenyl-diphosphate delta isomerase 1.	0.951
H2N0C8_ORYLA	msmo1	ENSORLP00000024830	ENSORLP00000010006	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.	0.975
H2N0C8_ORYLA	nsdhl	ENSORLP00000024830	ENSORLP00000008014	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.	0.952
H2N0C8_ORYLA	sqle	ENSORLP00000024830	ENSORLP00000003980	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	Squalene epoxidase a.	0.992
LOC100125499	H2N0C8_ORYLA	ENSORLP00000021654	ENSORLP00000024830	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	0.955
LOC100125499	LOC101157258	ENSORLP00000021654	ENSORLP00000042370	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.498
LOC100125499	LSS	ENSORLP00000021654	ENSORLP00000018804	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.498
LOC100125499	dhcr7	ENSORLP00000021654	ENSORLP00000019315	3-hydroxy-3-methylglutaryl coenzyme A reductase.	7-dehydrocholesterol reductase.	0.858
LOC100125499	fdft1	ENSORLP00000021654	ENSORLP00000021714	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Farnesyl-diphosphate farnesyltransferase 1.	0.912
LOC100125499	hmgcs1	ENSORLP00000021654	ENSORLP00000031232	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
LOC100125499	idi1	ENSORLP00000021654	ENSORLP00000006292	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Isopentenyl-diphosphate delta isomerase 1.	0.839
LOC100125499	msmo1	ENSORLP00000021654	ENSORLP00000010006	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.	0.743
LOC100125499	nsdhl	ENSORLP00000021654	ENSORLP00000008014	3-hydroxy-3-methylglutaryl coenzyme A reductase.	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.	0.638
LOC100125499	sqle	ENSORLP00000021654	ENSORLP00000003980	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Squalene epoxidase a.	0.979