Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
H2LDS1_ORYLAChromo domain-containing protein. (490 aa)    
Predicted Functional Partners:
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 0.783
ssrp1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
    
 
 0.723
rtf1
RTF1 homolog, Paf1/RNA polymerase II complex component.
   
 
 0.717
supt16h
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 
 0.716
leo1
LEO1 homolog, Paf1/RNA polymerase II complex component.
   
 
 0.706
rbbp5
Retinoblastoma binding protein 5.
    
 
 0.679
ash2l
Ash2 like, histone lysine methyltransferase complex subunit.
    
 
 0.670
btaf1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated.
  
 
 0.661
smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5.
  
 
0.635
setd2
SET domain containing 2, histone lysine methyltransferase.
   
 0.629
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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