STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101163990Protein kinase domain-containing protein. (1015 aa)    
Predicted Functional Partners:
LOC101163933
Mitogen-activated protein kinase kinase 6.
  
 
0.932
LOC101170843
Protein kinase domain-containing protein.
  
 
0.932
yap1
Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation.
    
 
 0.627
nudc
NudC nuclear distribution protein.
     
  0.571
mapre1
Microtubule-associated protein, RP/EB family, member 1b.
    
 0.560
bub1
BUB1 mitotic checkpoint serine/threonine kinase.
     
 0.556
rcc2
Regulator of chromosome condensation 2.
     
  0.548
ska2
SKA2 domain-containing protein.
     
  0.548
IGFBP3
Insulin like growth factor binding protein 3.
    
 0.539
mad2l1
HORMA domain-containing protein.
     
 0.509
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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