Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
rreb1Ras responsive element binding protein 1a. (1807 aa)    
Predicted Functional Partners:
kdm1a
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
    
 0.924
ctbp1
C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 
 0.793
LOC101158706
C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 
 0.793
LOC101168811
Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 
 0.793
ctbp2
Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 
 0.793
nfe2l2
Nuclear factor, erythroid 2-like 2a.
      
 0.716
pgr
Uncharacterized protein.
    
 0.703
zmym2
Zinc finger, MYM-type 2.
   
 0.685
rfx5
Regulatory factor X, 5.
    
 
 0.676
hook1
Hook microtubule-tethering protein 1.
    
 0.633
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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