Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ubr2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1798 aa)    
Predicted Functional Partners:
trip12
Thyroid hormone receptor interactor 12.
   
 0.992
eftud2
Elongation factor Tu GTP binding domain containing 2.
      
 0.781
ube2a
Ubiquitin-conjugating enzyme E2A (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family.
    
 0.777
ube2b
Ubiquitin-conjugating enzyme E2B (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family.
    
 0.777
LOC101155732
Ubiquitin conjugating enzyme E2 A, like; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.777
ubr4
Ubiquitin protein ligase E3 component n-recognin 4.
   
  
 0.742
MARCHF6
Membrane associated ring-CH-type finger 6.
   
 
 0.697
LOC101168653
RING-CH-type domain-containing protein.
   
 
 0.697
ubc
Ubiquitin B.
   
 0.693
rps27a
Ribosomal protein S27a.
   
 0.688
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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