LOC101171386 protein (Oryzias latipes) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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protein homology

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Score

LOC101171386

Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (660 aa)

Predicted Functional Partners:

prkn

0.968

pink1

0.952

rhot2

0.901

H2M6E4_ORYLA

0.799

LOC101165932

0.799

ENSORLP00000034742

0.799

ENSORLP00000036645

0.799

ENSORLP00000041578

0.799

ENSORLP00000032656

0.727

H2M6A2_ORYLA

0.687

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000032656	LOC101171386	ENSORLP00000032656	ENSORLP00000004309	Uncharacterized protein.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.727
ENSORLP00000032656	rhot2	ENSORLP00000032656	ENSORLP00000027890	Uncharacterized protein.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.727
ENSORLP00000034742	ENSORLP00000036645	ENSORLP00000034742	ENSORLP00000036645	Uncharacterized protein.	EH domain-containing protein.	0.962
ENSORLP00000034742	ENSORLP00000041578	ENSORLP00000034742	ENSORLP00000041578	Uncharacterized protein.	SH3 domain-containing protein.	0.962
ENSORLP00000034742	H2M6A2_ORYLA	ENSORLP00000034742	ENSORLP00000013992	Uncharacterized protein.	Intersectin 1 (SH3 domain protein).	0.995
ENSORLP00000034742	H2M6E4_ORYLA	ENSORLP00000034742	ENSORLP00000014038	Uncharacterized protein.	Uncharacterized protein.	0.995
ENSORLP00000034742	LOC101165932	ENSORLP00000034742	ENSORLP00000020940	Uncharacterized protein.	Intersectin 2a.	0.962
ENSORLP00000034742	LOC101171386	ENSORLP00000034742	ENSORLP00000004309	Uncharacterized protein.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.799
ENSORLP00000034742	rhot2	ENSORLP00000034742	ENSORLP00000027890	Uncharacterized protein.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.799
ENSORLP00000036645	ENSORLP00000034742	ENSORLP00000036645	ENSORLP00000034742	EH domain-containing protein.	Uncharacterized protein.	0.962
ENSORLP00000036645	ENSORLP00000041578	ENSORLP00000036645	ENSORLP00000041578	EH domain-containing protein.	SH3 domain-containing protein.	0.962
ENSORLP00000036645	H2M6A2_ORYLA	ENSORLP00000036645	ENSORLP00000013992	EH domain-containing protein.	Intersectin 1 (SH3 domain protein).	0.958
ENSORLP00000036645	H2M6E4_ORYLA	ENSORLP00000036645	ENSORLP00000014038	EH domain-containing protein.	Uncharacterized protein.	0.962
ENSORLP00000036645	LOC101165932	ENSORLP00000036645	ENSORLP00000020940	EH domain-containing protein.	Intersectin 2a.	0.962
ENSORLP00000036645	LOC101171386	ENSORLP00000036645	ENSORLP00000004309	EH domain-containing protein.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.799
ENSORLP00000036645	rhot2	ENSORLP00000036645	ENSORLP00000027890	EH domain-containing protein.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.799
ENSORLP00000041578	ENSORLP00000034742	ENSORLP00000041578	ENSORLP00000034742	SH3 domain-containing protein.	Uncharacterized protein.	0.962
ENSORLP00000041578	ENSORLP00000036645	ENSORLP00000041578	ENSORLP00000036645	SH3 domain-containing protein.	EH domain-containing protein.	0.962
ENSORLP00000041578	H2M6A2_ORYLA	ENSORLP00000041578	ENSORLP00000013992	SH3 domain-containing protein.	Intersectin 1 (SH3 domain protein).	0.958
ENSORLP00000041578	H2M6E4_ORYLA	ENSORLP00000041578	ENSORLP00000014038	SH3 domain-containing protein.	Uncharacterized protein.	0.962

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.792

expected number of edges:

10

PPI enrichment p-value:

3.85e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009166

Nucleotide catabolic process

7 of 52

2.39

5.76

1.11e-12

GO:0046496

Nicotinamide nucleotide metabolic process

5 of 24

2.58

4.57

1.57e-09

GO:0009394

2-deoxyribonucleotide metabolic process

5 of 27

2.53

4.46

2.24e-09

GO:0009125

Nucleoside monophosphate catabolic process

4 of 13

2.75

3.89

5.34e-08

GO:0009117

Nucleotide metabolic process

11 of 461

1.64

3.81

1.10e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008253

5-nucleotidase activity

5 of 13

2.85

5.01

4.22e-10

GO:0106411

XMP 5-nucleosidase activity

3 of 5

3.04

2.84

6.71e-06

GO:0050484

GMP 5-nucleotidase activity

2 of 2

3.26

1.75

0.00069

GO:0050146

Nucleoside phosphotransferase activity

2 of 2

3.26

1.75

0.00069

GO:0050483

IMP 5-nucleotidase activity

2 of 3

3.09

1.71

0.00081

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7146

Mixed, incl. Purine metabolism, and Nicotinate and nicotinamide metabolism

11 of 169

2.08

6.98

9.26e-20

CL:7147

Purine metabolism, and Nicotinate and nicotinamide metabolism

10 of 140

2.12

6.72

6.15e-18

CL:7238

Mixed, incl. 5-nucleotidase activity, and Purine salvage

6 of 22

2.7

6.06

2.07e-12

CL:7239

5-nucleotidase activity, and Adenosine deaminase

5 of 15

2.79

5.19

1.64e-10

CL:7379

Nicotinate and nicotinamide metabolism

4 of 19

2.59

3.57

1.72e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa00760

Nicotinate and nicotinamide metabolism

10 of 33

2.75

11.59

2.24e-24

cfa00240

Pyrimidine metabolism

5 of 42

2.34

4.23

2.76e-09

cfa00230

Purine metabolism

5 of 111

1.92

2.94

2.13e-07

cfa01100

Metabolic pathways

10 of 1220

1.18

1.69

1.16e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-196807

Nicotinate metabolism

6 of 25

2.64

5.79

5.73e-12

CFA-8956319

Nucleotide catabolism

4 of 31

2.37

3.09

9.87e-07

CFA-74259

Purine catabolism

3 of 16

2.54

2.42

3.02e-05

CFA-73621

Pyrimidine catabolism

2 of 8

2.66

1.44

0.0024

CFA-197264

Nicotinamide salvaging

2 of 14

2.42

1.22

0.0057

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0662

Pyridine nucleotide biosynthesis

2 of 7

2.72

1.32

0.0040

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06941

5 nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)

2 of 2

3.26

1.35

0.0037

PF05761

5 nucleotidase family

2 of 5

2.87

1.21

0.0065

PF00293

NUDIX domain

2 of 17

2.33

0.79

0.0351

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