zrsr2 protein (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

zrsr2

Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2. (590 aa)

Predicted Functional Partners:

u2af2

0.987

LOC101163660

0.791

LOC100049528

0.791

rnpc3

0.773

snrnp48

0.773

LOC101162697

0.758

LOC101171767

0.758

H2LC37_ORYLA

0.757

phf5a

0.744

LOC101155211

0.741

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2LC37_ORYLA	LOC101155211	ENSORLP00000003471	ENSORLP00000000917	Uncharacterized protein.	Serine and arginine rich splicing factor 7a.	0.636
H2LC37_ORYLA	LOC101162697	ENSORLP00000003471	ENSORLP00000005758	Uncharacterized protein.	Serine and arginine rich splicing factor 1a.	0.698
H2LC37_ORYLA	LOC101171767	ENSORLP00000003471	ENSORLP00000006698	Uncharacterized protein.	Uncharacterized protein.	0.698
H2LC37_ORYLA	zrsr2	ENSORLP00000003471	ENSORLP00000004323	Uncharacterized protein.	Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2.	0.757
LOC100049528	LOC101155211	ENSORLP00000026065	ENSORLP00000000917	Serine and arginine rich splicing factor 2a.	Serine and arginine rich splicing factor 7a.	0.873
LOC100049528	LOC101162697	ENSORLP00000026065	ENSORLP00000005758	Serine and arginine rich splicing factor 2a.	Serine and arginine rich splicing factor 1a.	0.877
LOC100049528	LOC101171767	ENSORLP00000026065	ENSORLP00000006698	Serine and arginine rich splicing factor 2a.	Uncharacterized protein.	0.877
LOC100049528	u2af2	ENSORLP00000026065	ENSORLP00000014464	Serine and arginine rich splicing factor 2a.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.815
LOC100049528	zrsr2	ENSORLP00000026065	ENSORLP00000004323	Serine and arginine rich splicing factor 2a.	Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2.	0.791
LOC101155211	H2LC37_ORYLA	ENSORLP00000000917	ENSORLP00000003471	Serine and arginine rich splicing factor 7a.	Uncharacterized protein.	0.636
LOC101155211	LOC100049528	ENSORLP00000000917	ENSORLP00000026065	Serine and arginine rich splicing factor 7a.	Serine and arginine rich splicing factor 2a.	0.873
LOC101155211	LOC101162697	ENSORLP00000000917	ENSORLP00000005758	Serine and arginine rich splicing factor 7a.	Serine and arginine rich splicing factor 1a.	0.960
LOC101155211	LOC101163660	ENSORLP00000000917	ENSORLP00000001513	Serine and arginine rich splicing factor 7a.	RRM domain-containing protein.	0.873
LOC101155211	LOC101171767	ENSORLP00000000917	ENSORLP00000006698	Serine and arginine rich splicing factor 7a.	Uncharacterized protein.	0.960
LOC101155211	u2af2	ENSORLP00000000917	ENSORLP00000014464	Serine and arginine rich splicing factor 7a.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.833
LOC101155211	zrsr2	ENSORLP00000000917	ENSORLP00000004323	Serine and arginine rich splicing factor 7a.	Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2.	0.741
LOC101162697	H2LC37_ORYLA	ENSORLP00000005758	ENSORLP00000003471	Serine and arginine rich splicing factor 1a.	Uncharacterized protein.	0.698
LOC101162697	LOC100049528	ENSORLP00000005758	ENSORLP00000026065	Serine and arginine rich splicing factor 1a.	Serine and arginine rich splicing factor 2a.	0.877
LOC101162697	LOC101155211	ENSORLP00000005758	ENSORLP00000000917	Serine and arginine rich splicing factor 1a.	Serine and arginine rich splicing factor 7a.	0.960
LOC101162697	LOC101163660	ENSORLP00000005758	ENSORLP00000001513	Serine and arginine rich splicing factor 1a.	RRM domain-containing protein.	0.877

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.91

expected number of edges:

11

PPI enrichment p-value:

4.18e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

4 of 5

2.73

3.42

4.23e-07

GO:0006289

Nucleotide-excision repair

3 of 11

2.26

1.98

0.00016

GO:0009432

SOS response

3 of 19

2.02

1.66

0.00052

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009381

Excinuclease ABC activity

3 of 10

2.3

1.76

0.00048

GO:0008965

Phosphoenolpyruvate-protein phosphotransferase activity

2 of 2

2.82

1.53

0.0017

GO:0004518

Nuclease activity

4 of 61

1.64

1.48

0.00048

GO:0016887

ATP hydrolysis activity

3 of 61

1.52

0.94

0.0096

GO:0140640

Catalytic activity, acting on a nucleic acid

4 of 245

1.04

0.6

0.0266

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009380

Excinuclease repair complex

3 of 10

2.3

2.11

9.25e-05

GO:0005737

Cytoplasm

8 of 1249

0.63

0.49

0.0024

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:18485189

(2008) Unraveling the evolutionary history of the phosphoryl-transfer chain of the phosphoenolpyruvate:phosphotransferase system through phylogenetic analyses and genome context.

5 of 6

2.74

5.21

1.31e-10

PMID:26257709

(2015) The reduced genomes of Parcubacteria (OD1) contain signatures of a symbiotic lifestyle.

3 of 24

1.92

1.68

0.00039

PMID:15886391

(2005) An SOS-regulated operon involved in damage-inducible mutagenesis in Caulobacter crescentus.

2 of 5

2.43

1.51

0.0016

PMID:23902135

(2013) GTAG- and CGTC-tagged palindromic DNA repeats in prokaryotes.

2 of 6

2.35

1.5

0.0016

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9636

Mixed, incl. Import across plasma membrane, and Mannoside phosphorylase

5 of 17

2.29

3.7

3.41e-08

CL:9655

Import across plasma membrane, and Type I phosphodiesterase / nucleotide pyrophosphatase

4 of 6

2.65

3.6

1.72e-07

CL:9634

Mostly uncharacterized, incl. Import across plasma membrane, and Glycosyl hydrolase, five-bladed beta-propellor domain superfamily

6 of 39

2.01

3.41

2.56e-08

CL:915

DNA excision

3 of 6

2.52

2.29

5.26e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rba02060

Phosphotransferase system (PTS)

4 of 5

2.73

3.97

3.71e-08

rba03420

Nucleotide excision repair

3 of 12

2.22

2.17

6.10e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009380

Excinuclease repair complex

3 of 10

2.3

1.97

0.00018

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0267

Excision nuclease

3 of 5

2.6

2.43

3.02e-05

KW-0228

DNA excision

3 of 5

2.6

2.43

3.02e-05

KW-0598

Phosphotransferase system

2 of 2

2.82

1.83

0.00046

KW-0762

Sugar transport

2 of 3

2.65

1.75

0.00063

KW-0670

Pyruvate

2 of 13

2.01

1.17

0.0057

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05524

PEP-utilising enzyme, N-terminal

2 of 2

2.82

1.16

0.0079

PF02896

PEP-utilising enzyme, PEP-binding domain

2 of 3

2.65

1.16

0.0079

PF00391

PEP-utilising enzyme, mobile domain

2 of 3

2.65

1.16

0.0079

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041102

UvrA, interaction domain

2 of 3

2.65

0.95

0.0192

IPR036637

Phosphohistidine domain superfamily

2 of 3

2.65

0.95

0.0192

IPR036618

PtsI, HPr-binding domain superfamily

2 of 2

2.82

0.95

0.0192

IPR024692

Phosphotransferase system, enzyme I

2 of 2

2.82

0.95

0.0192

IPR023151

PEP-utilising enzyme, conserved site

2 of 3

2.65

0.95

0.0192

(more ...)

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