Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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[Homology]
Score
dnajb4DnaJ heat shock protein family (Hsp40) member B4. (341 aa)    
Predicted Functional Partners:
stip1
Stress-induced phosphoprotein 1.
   
 0.878
hspa4
Heat shock protein 4b.
 
 0.861
LOC101166977
Heat shock protein 4a.
 
 0.859
hspa9
Heat shock protein 9; Belongs to the heat shock protein 70 family.
 
 0.852
hspa5
Uncharacterized protein; Belongs to the heat shock protein 70 family.
 
 0.839
hsp70-3
Uncharacterized protein; Belongs to the heat shock protein 70 family.
 
 0.811
hspa4l
Heat shock protein 4 like.
 
 0.803
hspa14
Heat shock protein 14; Belongs to the heat shock protein 70 family.
 
 0.793
DNAJA4
Uncharacterized protein.
  
0.778
hsc70
Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]
 
 0.777
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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