STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mapkapk5MAPK activated protein kinase 5. (469 aa)    
Predicted Functional Partners:
LOC101166150
Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family.
    
 0.999
mapk6
Mitogen-activated protein kinase 6.
    
 0.998
mapk4
Mitogen-activated protein kinase 4.
    
 0.982
LOC101175696
Mitogen-activated protein kinase.
   
0.968
LOC101154993
Mitogen-activated protein kinase.
   
0.968
LOC101159668
Mitogen-activated protein kinase.
   
0.968
H2MX42_ORYLA
Zgc:171775.
   
 0.968
LOC101160731
Mitogen-activated protein kinase.
   
0.968
LOC101162042
Mitogen-activated protein kinase.
   
0.968
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
    
 0.869
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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