STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)    
Predicted Functional Partners:
cdk6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
    
 0.965
cdk4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
    
 0.965
ccnd1
Cyclin D1; Belongs to the cyclin family.
    
 0.934
LOC101174910
Cyclin D2, a; Belongs to the cyclin family.
    
 0.934
LOC101175697
Cyclin D2, b; Belongs to the cyclin family.
    
 0.934
H2L3G9_ORYLA
Cyclin D3; Belongs to the cyclin family.
    
 0.920
LOC101163574
Cyclin Dx; Belongs to the cyclin family.
    
 0.913
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
    
 0.745
cdk1
Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II. Catalytic component of MPF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    
 0.671
LOC101162015
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.
  
   
 0.557
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.