Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (522 aa)    
Predicted Functional Partners:
apex1
DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
    
 0.972
msh2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
   
 
 0.899
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.881
LOC101166627
DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
    
 0.871
hus1
Checkpoint protein; Belongs to the HUS1 family.
    
 
 0.868
poll
Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.
    
 
 0.786
pold1
DNA polymerase.
  
  
 0.780
msh6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
   
 
 0.765
ogg1
8-oxoguanine DNA glycosylase.
  
  
 0.761
rad1
RAD1 homolog (S. pombe).
    
   0.759
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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