Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PIEZO2Piezo-type mechanosensitive ion channel component. (2749 aa)    
Predicted Functional Partners:
wdhd1
WD repeat and HMG-box DNA binding protein 1.
   
 
 0.822
mcm4
DNA helicase; Belongs to the MCM family.
   
 0.805
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
 0.794
tipin
TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.
   
 
 0.785
cdc6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.778
timeless
Timeless circadian clock.
   
 
 0.774
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
   
 
 0.767
mcm2
DNA helicase; Belongs to the MCM family.
   
 0.764
mcm9
Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family.
   
 0.764
tp53bp1
Tumor protein p53 binding protein, 1.
   
 
 0.754
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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