Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)    
Predicted Functional Partners:
ccnd1
Cyclin D1; Belongs to the cyclin family.
   
 0.997
rbl1
Retinoblastoma-like 1 (p107).
   
 0.988
LOC101174910
Cyclin D2, a; Belongs to the cyclin family.
   
 0.987
LOC101175697
Cyclin D2, b; Belongs to the cyclin family.
   
 0.987
rb1
Retinoblastoma 1.
   
 0.986
cdkn2b
Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4).
    
 0.984
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.984
cdkn2c
Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4).
   
 0.979
LOC101166216
Cyclin-dependent kinase inhibitor 1A.
   
 0.978
H2L3G9_ORYLA
Cyclin D3; Belongs to the cyclin family.
   
 0.977
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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